Evidence map›Paper›PMID 39138383›Full record

ArticleNature chemical biology2024

Shifting redox reaction equilibria on demand using an orthogonal redox cofactor.

Derek Aspacio, Yulai Zhang, Youtian Cui, Emma Luu, Edward King, William B Black, Sean Perea, Qiang Zhu, Yongxian Wu, Ray Luo and 2 more

Abstract read
In one paragraph

Article in Nature chemical biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Activation-Free Upgrading of Carboxylic Acids to Aldehydes and Alcohols.bioRxiv : the preprint server for biology · 2025
    Article
  9. Article
  10. Review
  11. Orthogonal redox control.Nature chemical biology · 2024
    Article
  12. EngineeringACS catalysis · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Derek Aspacio *Department of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, CA, USA.ORCID http://orcid.org/0000-0002-8210-1811
Yulai Zhang *Department of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, CA, USA.
Youtian Cui *Genome Center, University of California, Davis, Davis, CA, USA.
Emma LuuGenome Center, University of California, Davis, Davis, CA, USA.
Edward KingDepartment of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA.
William B BlackDepartment of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, CA, USA.ORCID http://orcid.org/0009-0007-2851-9997
Sean PereaDepartment of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, CA, USA.
Qiang ZhuDepartment of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, CA, USA.
Yongxian WuDepartment of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, CA, USA.
Ray LuoDepartment of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, CA, USA.ORCID http://orcid.org/0000-0002-6346-8271
Justin B SiegelGenome Center, University of California, Davis, Davis, CA, USA.
Han LiDepartment of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, CA, USA. han.li@uci.edu.ORCID http://orcid.org/0000-0002-6113-6433

Funding

Workshop on Environmental Technology Transfer and EntrepreneurshipP42ES004699 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI YOUNG, THOMAS MICHAEL · 1987 to 2021
$50.1M
Enzymatic formation of the hydrocarbon skeletons underlying diterpenoid diversityR01GM076324 · NIGMS · IOWA STATE UNIVERSITY · PI PETERS, REUBEN JOHN · 2006 to 2019
$3.4M
Multi-scaled Modeling of Electrostatic and Polarization Effects in BiomoleculesR35GM130367 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI RAY LUO · 2019 to 2026
$3.0M
Engineering an unnatural redox cofactor (uRedox) system for efficient biosynthesis of medicinesDP2GM137427 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI LI, HAN · 2019 to 2022
$2.4M
Expanding the Metabolic Currencies of LifeR35GM153401 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Han Li · 2024 to 2026
$1.4M
NIEHS NIH HHS P42 ES004699NIGMS NIH HHS DP2 GM137427NIGMS NIH HHS R01 GM076324NIGMS NIH HHS R35 GM130367NIGMS NIH HHS R35 GM153401
6 · The paper itself

Abstract

Nature's two redox cofactors, nicotinamide adenine dinucleotide (NAD

Indexed as

Escherichia coliNADPOxidation-ReductionBiocatalysisGlucose 1-DehydrogenaseModels, MolecularNADNicotinamide MononucleotideOxidoreductasesGlucose 1-DehydrogenaseNADNADPNicotinamide MononucleotideOxidoreductases

Identifiers

PMID39138383
PMCPMC12316058

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.