ArticleNature metabolism2024
Integration of epidemiological and blood biomarker analysis links haem iron intake to increased type 2 diabetes risk.
Article in Nature metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Metabolomic Profiles of Plant and Animal Protein and Type 2 Diabetes: Four Prospective US Cohort Studies.Research square · 2026Article
- The moderating role of central adiposity, sex and age, on the association between animal- and plant-based protein intake and the 20-year cumulative incidence of type 2 diabetes: the ATTICA cohort study (2002-2022).European journal of nutrition · 2026Article
- Intake of Fiber From Different Food Sources and Type 2 Diabetes Risk: An Integrated Analysis of Epidemiological and Multiomic Data.Diabetes care · 2026Article
- [Nutrition recommendations for people with diabetes (Update 2026)].Wiener klinische Wochenschrift · 2026Review
- Clinical Implications of the 2025-2030 Dietary Guidelines for Americans for Diabetes and Prediabetes Management.Journal of diabetes · 2026Article
- Epidemiological and Multi-Omics Investigation of Phytosterol Intake and Type 2 Diabetes Risk.Research square · 2026Article
- Lipidomic analyses of large cohort studies define the role of lipid metabolism in bridging diet and cardio-metabolic health.Nature communications · 2026Article
- Research progress of ferroptosis in obesity and its complications.Journal of physiology and biochemistry · 2026Review
- Substitution of White Meat for Red Meat and Diabetes Risk: A Prospective Cohort Study Stratified by Red Meat Intake.Nutrients · 2026Article
- Circulating metabolites, genetics and lifestyle factors in relation to future risk of type 2 diabetes.Nature medicine · 2026Article
- Bayesian Variable Selection for High-Dimensional Mediation Analysis: Application to Metabolomics Data in Epidemiological Studies.Statistics in medicine · 2026Article
- A low-protein diet drives short- and long-term improvements in metabolic health in a mouse model of sleeve gastrectomy.Cell reports. Medicine · 2025Article
- Chicken Liver from Broilers Fed Wheat Germ Expeller: A Source of Minerals and Energy in the Human Diet.Foods (Basel, Switzerland) · 2025Article
- Prospective study of circulating metabolomic profiles and breast cancer incidence among predominantly premenopausal women.British journal of cancer · 2025Observational
- Ultra-processed Plant Foods: Are They Worse than their Unprocessed Animal-Based Counterparts?Current nutrition reports · 2025Review
- Article
- Plasma Metabolome, Long-term Body Weight Change, and Type 2 Diabetes in U.S. Individuals.Diabetes care · 2025Article
- Ferritinophagy Is Involved in the Advanced Glycation End Products-Induced Ferroptosis of Vascular Endothelial Cells in Diabetes Mellitus.Journal of cellular and molecular medicine · 2025Article
- Dietary context in the association between red meat consumption and risk of type 2 diabetes.Metabolism: clinical and experimental · 2025Article
- Group-wise normalization in differential abundance analysis of microbiome samples.BMC bioinformatics · 2025Article
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Authors and funding
17 authors.
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Abstract
Dietary haem iron intake is linked to an increased risk of type 2 diabetes (T2D), but the underlying plasma biomarkers are not well understood. We analysed data from 204,615 participants (79% females) in three large US cohorts over up to 36 years, examining the associations between iron intake and T2D risk. We also assessed plasma metabolic biomarkers and metabolomic profiles in subsets of 37,544 (82% females) and 9,024 (84% females) participants, respectively. Here we show that haem iron intake but not non-haem iron is associated with a higher T2D risk, with a multivariable-adjusted hazard ratio of 1.26 (95% confidence interval 1.20-1.33; P for trend <0.001) comparing the highest to the lowest quintiles. Haem iron accounts for significant proportions of the T2D risk linked to unprocessed red meat and specific dietary patterns. Increased haem iron intake correlates with unfavourable plasma profiles of insulinaemia, lipids, inflammation and T2D-linked metabolites. We also identify metabolites, including L-valine and uric acid, potentially mediating the haem iron-T2D relationship, highlighting their pivotal role in T2D pathogenesis.
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