Evidence map›Paper›PMID 39138286›Full record

ArticleScientific reports2024

Inherited mitochondrial dysfunction triggered by OPA1 mutation impacts the sensory innervation fibre identity, functionality and regenerative potential in the cornea.

Léna Meneux, Nadège Feret, Sarah Pernot, Mélissa Girard, Solange Sarkis, Alicia Caballero Megido, Melanie Quiles, Agnès Müller, Laura Fichter, Jerome Vialaret and 3 more

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Léna MeneuxInstitute for Neurosciences of Montpellier, INSERM, University of Montpellier, Montpellier, France.
Nadège FeretInstitute for Neurosciences of Montpellier, INSERM, University of Montpellier, Montpellier, France.
Sarah PernotInstitute for Neurosciences of Montpellier, INSERM, University of Montpellier, Montpellier, France.
Mélissa GirardInstitute for Neurosciences of Montpellier, INSERM, University of Montpellier, Montpellier, France.
Solange SarkisInstitute for Neurosciences of Montpellier, INSERM, University of Montpellier, Montpellier, France.
Alicia Caballero MegidoInstitute for Neurosciences of Montpellier, INSERM, University of Montpellier, Montpellier, France.
Melanie QuilesInstitute for Neurosciences of Montpellier, INSERM, University of Montpellier, Montpellier, France.
Agnès MüllerInstitute for Neurosciences of Montpellier, INSERM, University of Montpellier, Montpellier, France.
Laura FichterInstitute for Neurosciences of Montpellier, INSERM, University of Montpellier, Montpellier, France.
Jerome VialaretInstitute for Neurosciences of Montpellier, INSERM, University of Montpellier, Montpellier, France.
Christophe HirtzInstitute for Neurosciences of Montpellier, INSERM, University of Montpellier, Montpellier, France.
Cecile DelettreInstitute for Neurosciences of Montpellier, INSERM, University of Montpellier, Montpellier, France.
Frederic MichonInstitute for Neurosciences of Montpellier, INSERM, University of Montpellier, Montpellier, France. frederic.michon@inserm.fr.

Funding

Agence Nationale de la Recherche ANR-21-CE17-0061, TeFiCoPaFondation de France 00143435 / WB-2023-48237Fondation pour la Recherche Médicale REP202110014140
6 · The paper itself

Abstract

Mitochondrial dysfunctions are detrimental to organ metabolism. The cornea, transparent outmost layer of the eye, is prone to environmental aggressions, such as UV light, and therefore dependent on adequate mitochondrial function. While several reports have linked corneal defects to mitochondrial dysfunction, the impact of OPA1 mutation, known to induce such dysfunction, has never been studied in this context. We used the mouse line carrying OPA1

Indexed as

CorneaGTP PhosphohydrolasesMitochondriaMutationAnimalsMiceRegenerationGTP PhosphohydrolasesOpa1 protein, mouseCorneaEpitheliumInnervationMitochondriaOPA1ProteomicTear filmTranscriptomic

Identifiers

PMID39138286
PMCPMC11322642

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.