ArticleNature communications2024
An unusual two-strain cholera outbreak in Lebanon, 2022-2023: a genomic epidemiology study.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Infectious diseases burden of health system collapse in Gaza and Lebanon: a call for action.The Lancet regional health. Europe · 2026Article
- Interspecies Exchange of Mobile Genetic Elements During a Plant Disease Outbreak.Genome biology and evolution · 2026Article
- Genomic analysis of Vibrio cholerae in Western Kenya (2015-2023) reveals persistence of pandemic ST69 and presence of the European-associated ST8 lineage.BMC genomics · 2026Article
- Evolution of pandemic cholera at its global source.Nature · 2026Article
- A Fitness Burden Drives the Reversion of in vitro Acquired Doxycycline Resistance inInfection and drug resistance · 2026Article
- In-silico identification of anti-cholera phytochemicals from Indian medicinal plants.PloS one · 2026Article
- Genomics reveals multiple introductions of the seventh pandemicMicrobial genomics · 2025Article
- Lineage-specific defence systems of pandemicPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Highly drug-resistant Vibrio cholerae harbouring blaPER-7 isolated from travellers returning to England.The Journal of antimicrobial chemotherapy · 2025Article
- Genomic characterization of multidrug-resistant extended-spectrum β-lactamase-producing Vibrio cholerae O1 strains from 2022 cholera outbreak in Kenya.The Journal of antimicrobial chemotherapy · 2025Article
- Plant-based edible vaccines: Can cholera be the case study in Africa?Journal, genetic engineering & biotechnology · 2025Review
- Recent and convergent reversion to serotype Ogawa in the AFR12 sublineage ofMicrobial genomics · 2025Article
- Descriptive Epidemiology of the 2022-2023 Cholera Outbreak in Lebanon and Lessons Learned in the Context of a Humanitarian Emergency Situation.Open forum infectious diseases · 2025Article
- Cholera outbreaks: Public health implications, economic burden, and preventive strategies.AIMS public health · 2025Review
- Cholera Outbreaks in Low- and Middle-Income Countries in the Last Decade: A Systematic Review and Meta-Analysis.Microorganisms · 2024Review
- Draft genomes of 10Microbiology resource announcements · 2024Article
- Genomic analysis ofEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2024Article
- Spotlight on the epidemiology and antimicrobial susceptibility profiles ofFuture microbiology · 2024Review
- Pre-Travel Consultation for the Prevention of Infectious Diseases among International Travelers from GCC Countries: Travel Medicine Recommendations for Clinicians.Saudi journal of medicine & medical sciencesReview
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26 authors.
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Abstract
Cholera is a life-threatening gastrointestinal infection caused by a toxigenic bacterium, Vibrio cholerae. After a lull of almost 30 years, a first case of cholera was detected in Lebanon in October 2022. The outbreak lasted three months, with 8007 suspected cases (671 laboratory-confirmed) and 23 deaths. In this study, we use phenotypic methods and microbial genomics to study 34 clinical and environmental Vibrio cholerae isolates collected throughout this outbreak. All isolates are identified as V. cholerae O1, serotype Ogawa strains from wave 3 of the seventh pandemic El Tor (7PET) lineage. Phylogenomic analysis unexpectedly reveals the presence of two different strains of the seventh pandemic El Tor (7PET) lineage. The dominant strain has a narrow antibiotic resistance profile and is phylogenetically related to South Asian V. cholerae isolates and derived African isolates from the AFR15 sublineage. The second strain is geographically restricted and extensively drug-resistant. It belongs to the AFR13 sublineage and clusters with V. cholerae isolates collected in Yemen. In conclusion, the 2022-2023 Lebanese cholera outbreak is caused by the simultaneous introduction of two different 7PET strains. Genomic surveillance with cross-border collaboration is therefore crucial for the identification of new introductions and routes of circulation of cholera, improving our understanding of cholera epidemiology.
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