Evidence map›Paper›PMID 39138203›Full record

Trial reportNature communications2024

Memory B cell responses induced by pneumococcal conjugate vaccine schedules with fewer doses: analysis of a randomised-controlled trial in Viet Nam.

Darren Suryawijaya Ong, Thanh V Phan, Beth Temple, Zheng Quan Toh, Cattram Duong Nguyen, Kien Vientrung, Hoang Van Anh Nguyen, Vo Thi Trang Dai, Kathryn Bright, Hau Phuc Tran and 5 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Trial
  3. The microbiological characteristics and diagnosis ofHuman vaccines & immunotherapeutics · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Darren Suryawijaya Ong *Infection, Immunity & Global Health, Murdoch Children's Research Institute, Parkville, VIC, Australia.ORCID 0000-0001-6409-1376
Thanh V Phan *Pasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Viet Nam.ORCID 0009-0006-5056-7285
Beth Temple *Infection, Immunity & Global Health, Murdoch Children's Research Institute, Parkville, VIC, Australia.
Zheng Quan TohInfection, Immunity & Global Health, Murdoch Children's Research Institute, Parkville, VIC, Australia.ORCID 0000-0002-0282-5837
Cattram Duong NguyenInfection, Immunity & Global Health, Murdoch Children's Research Institute, Parkville, VIC, Australia.ORCID 0000-0002-0599-8645
Kien VientrungPasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Viet Nam.
Hoang Van Anh NguyenPasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Viet Nam.
Vo Thi Trang DaiPasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Viet Nam.
Kathryn BrightInfection, Immunity & Global Health, Murdoch Children's Research Institute, Parkville, VIC, Australia.
Hau Phuc TranPasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Viet Nam.
Rachel Ann HigginsInfection, Immunity & Global Health, Murdoch Children's Research Institute, Parkville, VIC, Australia.
Yin Bun CheungCentre for Quantitative Medicine and Program in Health Services & Systems Research, Duke-NUS Medical School, Singapore, Singapore.
Thuong Vu NguyenPasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Viet Nam.
Kim MulhollandInfection, Immunity & Global Health, Murdoch Children's Research Institute, Parkville, VIC, Australia.
Paul Vincent LicciardiInfection, Immunity & Global Health, Murdoch Children's Research Institute, Parkville, VIC, Australia. paul.licciardi@mcri.edu.au.ORCID 0000-0001-6086-6285

Funding

Gates Foundation INV-008627
6 · The paper itself

Abstract

The use of pneumococcal conjugate vaccine (PCV) schedules with fewer doses are being considered to reduce costs and improve access, particularly in low- and middle-income countries. While several studies have assessed their immunogenicity, there are limited data on their potential for long-term immune protection, as assessed by pneumococcal serotype-specific memory B cell (B

Indexed as

Immunization ScheduleMemory B CellsPneumococcal InfectionsPneumococcal VaccinesStreptococcus pneumoniaeAntibodies, BacterialChild, PreschoolFemaleHumansImmunoglobulin GInfantMaleSerogroupVaccinationVaccines, ConjugateVietnam10-valent pneumococcal conjugate vaccine13-valent pneumococcal vaccineAntibodies, BacterialImmunoglobulin GPneumococcal VaccinesVaccines, Conjugate

Identifiers

PMID39138203
PMCPMC11322157

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.