Evidence map›Paper›PMID 39138181›Full record

ArticleNature communications2024

Dysfunctional tumor-infiltrating Vδ1 + T lymphocytes in microsatellite-stable colorectal cancer.

Victoria Stary, Ram V Pandey, Julia List, Lisa Kleissl, Florian Deckert, Julijan Kabiljo, Johannes Laengle, Vasileios Gerakopoulos, Rudolf Oehler, Lukas Watzke and 7 more

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. γδ T cells and cancer.The Journal of clinical investigation · 2026
    Review
  3. γδ T cells in colorectal and liver cancer.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Harnessing Vδ1Frontiers in immunology · 2026
    Review
  10. Review
  11. Review
  12. The protective role of γδ T cells in endometrial cancer.Cancer immunology, immunotherapy : CII · 2025
    Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Victoria StaryMedical University of Vienna, Department of General Surgery, Division of Visceral Surgery, Comprehensive Cancer Center, Vienna, Austria. victoria.stary@meduniwien.ac.at.ORCID 0000-0002-3854-9934
Ram V PandeyMedical University of Vienna, Department of Dermatology, Vienna, Austria.
Julia ListMedical University of Vienna, Department of General Surgery, Division of Visceral Surgery, Comprehensive Cancer Center, Vienna, Austria.ORCID 0000-0002-4199-3198
Lisa KleisslMedical University of Vienna, Department of Dermatology, Vienna, Austria.ORCID 0000-0001-8011-796X
Florian DeckertCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Julijan KabiljoMedical University of Vienna, Department of General Surgery, Division of Visceral Surgery, Comprehensive Cancer Center, Vienna, Austria.
Johannes LaengleMedical University of Vienna, Department of General Surgery, Division of Visceral Surgery, Comprehensive Cancer Center, Vienna, Austria.ORCID 0000-0003-4771-1398
Vasileios GerakopoulosMedical University of Vienna, Department of General Surgery, Division of Visceral Surgery, Comprehensive Cancer Center, Vienna, Austria.ORCID 0000-0002-8551-2739
Rudolf OehlerMedical University of Vienna, Department of General Surgery, Division of Visceral Surgery, Comprehensive Cancer Center, Vienna, Austria.ORCID 0000-0003-2891-7155
Lukas WatzkeMedical University of Vienna, Department of Pathology, Vienna, Austria.
Matthias FarlikMedical University of Vienna, Department of Dermatology, Vienna, Austria.ORCID 0000-0003-0698-2992
Samuel W LukowskiDepartment of Human Cancer Immunology, Boehringer Ingelheim RCV GmBH & Co KG., Dr. Boehringer Gasse 5-11, 1120, Vienna, Austria.ORCID 0000-0002-8598-7902
Anne B VogtDepartment of Human Cancer Immunology, Boehringer Ingelheim RCV GmBH & Co KG., Dr. Boehringer Gasse 5-11, 1120, Vienna, Austria.
Georg StaryMedical University of Vienna, Department of Dermatology, Vienna, Austria.ORCID 0000-0003-1746-4250
Hannes StockingerMedical University of Vienna, Center for Pathophysiology, Infectiology and Immunology, Institute for Hygiene and Applied Immunology, Vienna, Austria.ORCID 0000-0001-6404-4430
Michael BergmannMedical University of Vienna, Department of General Surgery, Division of Visceral Surgery, Comprehensive Cancer Center, Vienna, Austria.ORCID 0000-0001-8529-1166
Nina PilatMedical University of Vienna, Department of General Surgery, Division of Visceral Surgery, Comprehensive Cancer Center, Vienna, Austria.ORCID 0000-0003-4071-9397

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although γδ T cells are known to participate in immune dysregulation in solid tumors, their relevance to human microsatellite-stable (MSS) colorectal cancer (CRC) is still undefined. Here, using integrated gene expression analysis and T cell receptor sequencing, we characterized γδ T cells in MSS CRC, with a focus on Vδ1 + T cells. We identified Vδ1

Indexed as

Colorectal NeoplasmsLymphocytes, Tumor-InfiltratingMicrosatellite InstabilityReceptors, Antigen, T-Cell, gamma-deltaReceptors, ImmunologicComplementarity Determining RegionsFemaleGene Expression Regulation, NeoplasticHumansMaleMicrosatellite RepeatsComplementarity Determining RegionsReceptors, Antigen, T-Cell, gamma-deltaReceptors, ImmunologicTIGIT protein, human

Identifiers

PMID39138181
PMCPMC11322529

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.