ArticleNature communications2024
Altering traits and fates of wild populations with Mendelian DNA sequence modifying Allele Sails.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- The LAST Mile: Evaluating Genetic Biocontrol as a Supplemental Tool for Eradicating Invasive Rodents on Islands.Evolutionary applications · 2026Article
- Emerging trends in genome editing of wild animals.Transgenic research · 2026Review
- Leveraging sex determination systems for genetic biocontrol of dipteran pests.Current opinion in insect science · 2026Review
- Applications and status of gene drive in plants.PLoS biology · 2025Article
- A Comparative Assessment of Self-limiting Genetic Control Strategies for Population Suppression.Molecular biology and evolution · 2025Article
- Expanding the CRISPR base editing toolbox in Drosophila melanogaster.Communications biology · 2024Article
- Public attitudes to genetic technology for invasive pest control and preferences for engagement and information: a segmentation analysis.Frontiers in bioengineering and biotechnology · 2024Article
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Authors and funding
3 authors.
Funding
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Abstract
Population-scale genome modification can alter the composition or fate of wild populations. Synthetic gene drives provide one set of tools, but their use is complicated by scientific, regulatory, and social issues associated with transgene persistence and flow. Here we propose an alternative approach. An Allele Sail consists of a genome editor (the Wind) that introduces DNA sequence edits, and is inherited in a Mendelian fashion. Meanwhile, the edits (the Sail) experience an arithmetic, Super-Mendelian increase in frequency. We model this system and identify contexts in which a single, low frequency release of an editor brings edits to a very high frequency. We also identify conditions in which manipulation of sex determination can bring about population suppression. In regulatory frameworks that distinguish between transgenics (GMO) and their edited non-transgenic progeny (non-GMO) Allele Sails may prove useful since the spread and persistence of the GM component can be limited.
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