Evidence map›Paper›PMID 39138099›Full record

ArticleInternational dental journal2025

Research Trends in the Comorbidity Between Periodontitis and Neurodegenerative Diseases.

Jiale Han, Yihan Liu, Xiaoyang Guo, Ge Gao, Qihui Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International dental journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jiale HanShanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China; Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China.
Yihan LiuDepartment of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Xiaoyang GuoTongji University School of Medicine, Shanghai, China.
Ge GaoCenter for Translational Neurodegeneration and Regenerative Therapy, Tongji Hospital Affiliated to Tongji University School of Medicine, Shanghai, China. Electronic address: ggao@tongji.edu.cn.
Qihui WuShanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China. Electronic address: qihuiwu@tongji.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

INTRODUCTION AND

aimsEvidence suggests an association between periodontitis and neurodegenerative diseases, but a comprehensive analysis of research trends remains absent. Therefore, we aim to identify research trends and hotspots on the comorbidity between periodontitis and neurodegenerative diseases, understand mechanisms, provide guidance for subsequent studies and show its clinical translational possibility.

methodsA bibliometric analysis covering 1982 to 2023 was conducted using the Web of Science Core Collection. English-language articles range from January 1, 1982 to November 30, 2023 were analyzed. Data were downloaded on November 30, 2023 and analyzed on December, 2023. Data visualization and statistical analysis were performed to identify trends of annual publications, countries, sources, institutions, authors, most cited articles, and keywords by using Microsoft Excel, VOSviewer, Citespace, R-bibliometrix and Origin Pro.

resultsA total of 1,238 articles from 1982 to 2023 on the comorbidity between periodontitis and neurodegenerative diseases were identified. Annual publications showed an upward trend. The United States, University College of London, BRAIN and Shy, Michael E. were the leading nation, affiliation, source and author, respectively. The United States, NEUROLOGY, and Curtis Maurice A. were the most cited nation, source, and author. Keywords network analysis highlighted 'Charcot-Marie-Tooth Disease', 'Alzheimer's Disease' and 'Periodontitis' as focal points. Detection of keywords citation bursts demonstrated 'Porphyromonas gingivalis' and 'Cognitive Dysfunction' as hot topics in recent research.

conclusionsIn recent years, emerging interests of the comorbidity between periodontitis and neurodegenerative diseases (NDs) are growing. Our study enhances the understanding of recent research trends of periodontitis and NDs and provides valuable perspectives within this expanding field, offering new insights into research trends regarding the interplay between 'Porphyromonas gingivalis' and 'Cognitive Dysfunction'. Further research of the molecular mechanisms between P. gingivalis-induced periodontitis, neuroinflammation, that leads neurodegeneration are clearly warranted.

Indexed as

Biomedical ResearchNeurodegenerative DiseasesPeriodontitisBibliometricsComorbidityHumansBibliometric analysisNeurodegenerationNeurodegenerative diseasesNeuroinflammationPeriodontitis

Identifiers

PMID39138099
PMCPMC11976591

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.