Evidence map›Paper›PMID 39137861›Full record

ArticleNeurobiology of learning and memory2024

The weekend warrior effect: Consistent intermittent exercise induces persistent cognitive benefits.

Scott La Tour, Hassan Shaikh, Joy H Beardwood, Agatha S Augustynski, Marcelo A Wood, Ashley A Keiser

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of learning and memory, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Scott La TourDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697, USA; Center for the Neurobiology of Learning and Memory (CNLM), University of California Irvine, Irvine, CA 92697, USA.
Hassan ShaikhDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697, USA; Center for the Neurobiology of Learning and Memory (CNLM), University of California Irvine, Irvine, CA 92697, USA.
Joy H BeardwoodDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697, USA; Center for the Neurobiology of Learning and Memory (CNLM), University of California Irvine, Irvine, CA 92697, USA.
Agatha S AugustynskiDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697, USA; Center for the Neurobiology of Learning and Memory (CNLM), University of California Irvine, Irvine, CA 92697, USA.
Marcelo A WoodDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697, USA; Center for the Neurobiology of Learning and Memory (CNLM), University of California Irvine, Irvine, CA 92697, USA. Electronic address: mwood@uci.edu.
Ashley A KeiserDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697, USA; Center for the Neurobiology of Learning and Memory (CNLM), University of California Irvine, Irvine, CA 92697, USA. Electronic address: Ashley.keiser@asu.edu.

Funding

Investigating the interface of epigenetics and metabolism underlying memory formation in the adult, aging, and AD brainR01AG076835 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Marcelo Andres Wood · 2022 to 2026
$3.6M
Delineating how epigenetic regulation of ACVR1C contributes to age and AD-related memory impairments in females and malesR00AG078501 · NIA · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI Ashley A Keiser · 2025 to 2026
$493k
Delineating how epigenetic regulation of ACVR1C contributes to age and AD-related memory impairments in females and malesK99AG078501 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI KEISER, ASHLEY A · 2022 to 2023
$219k
Determining how the epigenome serves as the interface between exercise and facilitated memory formation in the adult and aging female and male brainF32AG071209 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI KEISER, ASHLEY A · 2021 to 2021
$66k
NIA NIH HHS F32 AG071209NIA NIH HHS K99 AG078501NIA NIH HHS R00 AG078501NIA NIH HHS R01 AG076835
6 · The paper itself

Abstract

Exercise provides a range of cognitive benefits, including improved memory performance. Previously, we demonstrated that 14 days of continuous voluntary wheel-running exercise enables learning in a hippocampus-dependent Object Location Memory (OLM) task under insufficient, subthreshold training conditions in adult mice. Whether similar exercise benefits can be obtained from consistent intermittent exercise as continuous exercise is unknown. Here, we examine whether intermittent exercise (the weekend warrior effect: 2 days of exercise a week for 7 weeks) displays similar or distinct cognitive benefits as previously examined with 14 days of continuous exercise. We find that both continuous and intermittent exercise parameters similarly enable hippocampus-dependent OLM compared to the 2-day exercise control group. Mice receiving intermittent exercise maintained cognitive benefits following a 7-day sedentary delay, whereas mice that underwent 14 continuous days of exercise showed diminished cognitive benefits as previously reported. Further, compared to continuous exercise, intermittent exercise mice exhibited persistently elevated levels of the genes Acvr1c and Bdnf which we know to be critically involved in hippocampus-dependent long-term memory in the dorsal hippocampus. Together findings suggest that consistent intermittent exercise persistently enables hippocampal-dependent long-term memory. Understanding the optimal parameters for persistent cognitive function and the mechanisms mediating persistent effects will aid in therapeutic pursuits investigating the mitigation of cognitive ailments.

Indexed as

Brain-Derived Neurotrophic FactorHippocampusMice, Inbred C57BLPhysical Conditioning, AnimalAnimalsCognitionMaleMemory, Long-TermMiceSpatial MemoryBdnf protein, mouseBrain-Derived Neurotrophic FactorACVR1CBDNFCognitive BenefitContinuous ExerciseHippocampusIntermittent ExerciseLong Term MemoryMemoryObject Location MemoryWeekend Warrior

Identifiers

PMID39137861
PMCPMC11824922

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.