Evidence map›Paper›PMID 39137767›Full record

ArticleThe American journal of tropical medicine and hygiene2024

Intestinal Parasitic Infections May Be Overlooked Drivers of the Tuberculosis Pandemic.

Lili B Steel, Prakash Babu Narasimhan, Megha Chaudhari, Madolyn R Dauphinais, Samantha Huang, Kaley Beall, Madeline E Carwile, Chelsie Cintron, Xinyi Du, Scott K Heysell and 3 more

Abstract read
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lili B SteelSection of Infectious Diseases, Boston Medical Center, Boston, Massachusetts.
Prakash Babu NarasimhanDepartment of Immunology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
Megha ChaudhariDepartment of Microbiology, All India Institute of Medical Sciences, New Delhi, India.
Madolyn R DauphinaisSection of Infectious Diseases, Boston Medical Center, Boston, Massachusetts.
Samantha HuangSection of Infectious Diseases, Boston Medical Center, Boston, Massachusetts.
Kaley BeallSection of Infectious Diseases, Boston Medical Center, Boston, Massachusetts.
Madeline E CarwileSection of Infectious Diseases, Boston Medical Center, Boston, Massachusetts.
Chelsie CintronSection of Infectious Diseases, Boston Medical Center, Boston, Massachusetts.
Xinyi DuSection of Infectious Diseases, Boston Medical Center, Boston, Massachusetts.
Scott K HeysellDivision of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia.
Subitha LakshminarayananDepartment of Preventive and Social Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
Urvashi B SinghDepartment of Microbiology, All India Institute of Medical Sciences, New Delhi, India.
Pranay SinhaSection of Infectious Diseases, Boston Medical Center, Boston, Massachusetts.

Funding

Urine Colorimetry for Tuberculosis Pharmacokinetics Evaluation in Children and AdultsR01AI137080 · NIAID · UNIVERSITY OF VIRGINIA · PI Scott K Heysell, Leonid Kagan · 2018 to 2026
$6.3M
Nutritional Interventions to End Tuberculosis among Persons with HIV (NUTRIENT)K01AI167733 · NIAID · BOSTON MEDICAL CENTER · PI Pranay Sinha · 2023 to 2026
$512k
NIAID NIH HHS K01 AI167733NIAID NIH HHS R01 AI137080
6 · The paper itself

Abstract

The burden of tuberculosis (TB) is disproportionate in tropical and subtropical regions, where parasitic coinfections are common. Given the significant geographical overlap between TB and intestinal parasitic infections, it is important to consider the implications of intestinal parasitic infections for the TB pandemic. Intestinal parasitic infections have been theorized to increase vulnerability to TB by altering the inflammatory milieu, inducing undernutrition that blunts the immune response, and affecting drug pharmacokinetics. In this perspective, we provide a background of the epidemiological and immunological evidence that links parasitic infections to increased risk of TB progression and worse treatment outcomes. We also identify gaps in our knowledge and call for increased research on TB-parasitic coinfections to ensure action on a potentially widespread TB comorbidity.

Indexed as

CoinfectionIntestinal Diseases, ParasiticTuberculosisHumansPandemics

Identifiers

PMID39137767
PMCPMC11448528

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.