Evidence map›Paper›PMID 39137431›Full record

ArticleBiological research for nursing2025

Associations Between Preoperative Shortness of Breath and Potassium Channels Gene Variations in Women With Breast Cancer.

Joosun Shin, Marilyn J Hammer, Steven M Paul, Yvette P Conley, Carolyn Harris, Kate Oppegaard, Lisa Morse, Bruce A Cooper, Jon D Levine, Christine Miaskowski

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological research for nursing, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Joosun ShinDana-Farber Cancer Institute, Boston, MA, USA.
Marilyn J HammerDana-Farber Cancer Institute, Boston, MA, USA.
Steven M PaulSchool of Nursing, University of California San Francisco, San Francisco, CA, USA.
Yvette P ConleySchool of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-1784-6067
Carolyn HarrisSchool of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-7080-4990
Kate OppegaardVA Portland Health Care System, Portland, OR, USA.
Lisa MorseSchool of Nursing, University of California San Francisco, San Francisco, CA, USA.
Bruce A CooperSchool of Nursing, University of California San Francisco, San Francisco, CA, USA.
Jon D LevineVA Portland Health Care System, Portland, OR, USA.
Christine MiaskowskiSchool of Nursing, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0001-5170-2027

Funding

Symptom Management After Breast Cancer SurgeryR01CA107091 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MIASKOWSKI, CHRISTINE A. · 2003 to 2008
$4.5M
Long-term Arm Morbidity Following Breast Cancer TreatmentR01CA118658 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MIASKOWSKI, CHRISTINE A. · 2006 to 2010
$3.5M
Influence of Social Determinants of Health and Epigenomics on Psychological Symptom Cluster SeverityK99CA286967 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HARRIS, CAROLYN STIGGE · 2024 to 2025
$323k
NCI NIH HHS K99 CA286967NCI NIH HHS R01 CA107091NCI NIH HHS R01 CA118658
6 · The paper itself

Abstract

objectivesShortness of breath is a common symptom in patients with cancer. However, the mechanisms that underlie this troublesome symptom are poorly understood. Therefore, this study aimed to determine the prevalence of and associated risk factors for shortness of breath in women prior to breast cancer surgery and identify associations between shortness of breath and polymorphisms for potassium channel genes.

methodsPatients were recruited prior to breast cancer surgery and completed a self-report questionnaire on the occurrence of shortness of breath. Genotyping of single nucleotides polymorphism (SNPs) in potassium channel genes was performed using a custom array. Multiple logistic regression analyses were done to identify associations between the occurrence of shortness of breath and SNPs in ten candidate genes.

resultsOf the 398 patients, 11.1% reported shortness of breath. These patients had a lower annual household income, a higher comorbidity burden, and a lower functional status. After controlling for functional status, comorbidity burden, genomic estimates of ancestry and self-reported race and ethnicity, the genetic associations that remained significant in the multiple regression analyses were for potassium voltage-gated channel subfamily D (

conclusionsWhile these findings warrant replication, they suggest that alterations in potassium channel function may contribute to the occurrence of shortness of breath in women prior to breast cancer surgery.

Indexed as

Breast NeoplasmsDyspneaPotassium ChannelsAdultAgedFemaleHumansMiddle AgedPolymorphism, Single NucleotidePreoperative PeriodRisk FactorsSurveys and QuestionnairesPotassium Channelsbreast cancerpotassium channelsshortness of breathsingle nucleotide polymorphisms

Identifiers

PMID39137431
PMCPMC11788816

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.