Evidence map›Paper›PMID 39136994›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Cortical neurodegeneration caused by

Kuo Yan, Chen Zhang, Jongkyun Kang, Paola Montenegro, Jie Shen

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Correlations ofAlzheimer's & dementia (New York, N. Y.)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kuo YanDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Chen ZhangDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Jongkyun KangDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Paola MontenegroDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.ORCID 0000-0001-7521-1206
Jie ShenDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.ORCID 0000-0003-1160-7118

Funding

Role of Presenilins in the SynapseR01NS041783 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI Jie Shen · 2001 to 2026
$10.6M
Development of novel therapies for FADRF1AG063520 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI SHEN, JIE · 2019 to 2019
$3.9M
HHS | National Institutes of Health (NIH) R01NS041783HHS | National Institutes of Health (NIH) RF1AG063520NIA NIH HHS RF1 AG063520NINDS NIH HHS R01 NS041783
6 · The paper itself

Abstract

Mutations in the

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesCerebral CortexMutationPresenilin-1Amyloid beta-Protein PrecursorAmyloid Precursor Protein SecretasesAnimalsHumansMiceMice, TransgenicNeuronsAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAmyloid Precursor Protein SecretasesPresenilin-1presenilin 1, mouseAlzheimer’s diseaseapoptosisAPPgliosisPresenilin

Identifiers

PMID39136994
PMCPMC11348310

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.