Evidence map›Paper›PMID 39136899›Full record

ReviewCurrent cardiology reports2024

Recent Advances in Positron Emission Tomography Radiotracers to Image Cardiac Amyloidosis.

Ardel J Romero Pabón, Olivier F Clerc, Shilpa Vijayakumar, Sarah A M Cuddy, Sharmila Dorbala

Abstract readReview
In one paragraph

Review in Current cardiology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Preclinical and preliminary clinical evaluation of [European journal of nuclear medicine and molecular imaging · 2026
    Trial
  2. Head-to-head comparison ofEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ardel J Romero PabónDivision of Cardiology, Department of Medicine, Cardiac Amyloidosis Program, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Olivier F ClercDivision of Cardiology, Department of Medicine, Cardiac Amyloidosis Program, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Shilpa VijayakumarDivision of Cardiology, Department of Medicine, Cardiac Amyloidosis Program, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Sarah A M CuddyDivision of Cardiology, Department of Medicine, Cardiac Amyloidosis Program, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Sharmila DorbalaDivision of Cardiology, Department of Medicine, Cardiac Amyloidosis Program, Brigham and Women's Hospital, Boston, Massachusetts, USA. sdorbala@bwh.harvard.edu.

Funding

Noninvasive Cardiovascular Imaging Research Training ProgramT32HL094301 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Marcelo F DI CARLI · 2010 to 2026
$7.8M
Personalized Exercise Training to Improve Functional Capacity in Transthyretin Cardiac AmyloidosisK23HL166686 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Sarah AM Cuddy · 2023 to 2026
$756k
Mentoring Patient Oriented Research in Innovative Imaging and High-dimensional Data Approaches to Improve Outcomes in Cardiac AmyloidosisK24HL157648 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DORBALA, SHARMILA · 2021 to 2025
$612k
Elucidating Mechanisms of Cardiac Dysfunction Using Imaging and ProteomicsK99HL175107 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CLERC, OLIVIER FLORIAN · 2024 to 2025
$214k
NHLBI NIH HHS K23 HL166686NHLBI NIH HHS K24 HL157648NHLBI NIH HHS K99 HL175107NHLBI NIH HHS T32 HL094301
6 · The paper itself

Abstract

Cardiac amyloidosis includes a group of protein-misfolding diseases characterized by fibril accumulation within the extracellular space of the myocardium and cardiac dysfunction. Cardiac amyloidosis has high mortality. Emerging radionuclide techniques have helped us to better understand disease pathogenesis, prognostication, and treatment response in cardiac amyloidosis. PURPOSE OF REVIEW: To review recent advances in molecular imaging of cardiac amyloidosis using amyloid PET radiotracers. RECENT

findingsMultiple single center studies have shown that amyloid PET radiotracers allow definitive diagnosis and quantification of cardiac amyloid burden. These amyloid targeting tracers may provide means to improve early disease detection, risk stratification and treatment monitoring. Amyloid PET imaging may inform definitive imaging-based diagnosis for therapeutic decisions, risk stratification, and treatment monitoring. More research in unselected cohorts of patients with suspected cardiac amyloidosis is needed to optimize the clinical implementation of amyloid PET imaging.

Indexed as

AmyloidosisCardiomyopathiesPositron-Emission TomographyAmyloidHumansMyocardiumRadiopharmaceuticalsAmyloidRadiopharmaceuticalsCardiac AmyloidosisPositron Emission TomographyRadiotracers

Identifiers

PMID39136899
PMCPMC12270487

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.