Evidence map›Paper›PMID 39136824›Full record

ArticleAIDS and behavior2024

Factors Associated with Usage of Oral-PrEP among Female Sex Workers in Nairobi, Kenya, Assessed by Self-Report and a Point-of-Care Urine Tenofovir Immunoassay.

Pooja Shah, Matthew Spinelli, Erastus Irungu, Rhoda Kabuti, Pauline Ngurukiri, Hellen Babu, Mary Kungu, The Maisha Fiti Study Champions, Chrispo Nyabuto, Anne Mahero and 10 more

Abstract read
In one paragraph

Article in AIDS and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Pooja ShahDepartment of Global Health and Development, Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK. Pooja.shah@lshtm.ac.uk.ORCID http://orcid.org/0000-0001-5101-8129
Matthew SpinelliDivision of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-6368-8664
Erastus IrunguPartners for Health and Development in Africa (PHDA), Nairobi, Kenya.
Rhoda KabutiPartners for Health and Development in Africa (PHDA), Nairobi, Kenya.ORCID http://orcid.org/0000-0002-9541-3742
Pauline NgurukiriPartners for Health and Development in Africa (PHDA), Nairobi, Kenya.
Hellen BabuPartners for Health and Development in Africa (PHDA), Nairobi, Kenya.ORCID http://orcid.org/0000-0002-2570-6531
Mary KunguPartners for Health and Development in Africa (PHDA), Nairobi, Kenya.ORCID http://orcid.org/0000-0002-0331-3825
The Maisha Fiti Study ChampionsDepartment of Global Health and Development, Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.
Chrispo NyabutoPartners for Health and Development in Africa (PHDA), Nairobi, Kenya.
Anne MaheroPartners for Health and Development in Africa (PHDA), Nairobi, Kenya.
Karen DevriesDepartment of Global Health and Development, Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.ORCID http://orcid.org/0000-0001-8935-2181
Nambusi KyegombeDepartment of Global Health and Development, Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.ORCID http://orcid.org/0000-0002-3986-0361
Graham F MedleyDepartment of Global Health and Development, Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.ORCID http://orcid.org/0000-0002-0030-7278
Mitzy GafosDepartment of Global Health and Development, Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.ORCID http://orcid.org/0000-0002-7894-1498
Janet SeeleyDepartment of Global Health and Development, Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.ORCID http://orcid.org/0000-0002-0583-5272
Helen A WeissMRC International Statistics & Epidemiology Group, Department of Infectious Disease Epidemiology and International Health, London School of Hygiene and Tropical Medicine, London, UK.ORCID http://orcid.org/0000-0003-3547-7936
Rupert KaulDepartments of Immunology and Medicine, University of Toronto, Toronto, Canada.ORCID http://orcid.org/0000-0002-1586-4093
Monica GandhiDivision of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-7025-1994
Tara S Beattie *Department of Global Health and Development, Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.ORCID http://orcid.org/0000-0001-9156-7341
Joshua Kimani *Partners for Health and Development in Africa (PHDA), Nairobi, Kenya.ORCID http://orcid.org/0000-0003-2858-5007

Funding

Randomized Trial to Optimize Virologic Suppression Rates Using a Point-of-Care Urine Monitoring Assay (ROVING-PUMA)R01AI143340 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Monica Gandhi · 2018 to 2026
$5.6M
PrEP Point-of-Care Brief-Intervention for Adherence among Young Men Who Have Sex with Men (PrEP2-BAY Study)K23MH122286 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SPINELLI, MATTHEW A. · 2020 to 2024
$1.0M
Commonwealth Scholarship Commission KECS-2019-843Medical Research Council MR/R023182/1NIAID NIH HHS R01 AI143340NIH HHS K23MH122286NIH HHS R01AI143340NIMH NIH HHS K23 MH122286
6 · The paper itself

Abstract

Pre-exposure prophylaxis (PrEP) is highly effective at reducing HIV acquisition. We aimed to estimate usage of oral-PrEP, and factors associated with adherence among female sex workers (FSWs) in Nairobi, Kenya, using a novel point-of-care urine tenofovir lateral flow assay (LFA). The Maisha Fiti study randomly selected FSWs from Sex Worker Outreach Program clinics in Nairobi. Data were collected from 1003 FSWs from June-October 2019, including surveys on self-reported oral-PrEP adherence. Adherence was also measured using the LFA for HIV-negative FSWs currently taking oral-PrEP. Informed by a social-ecological theoretical framework, we used hierarchical multivariable logistic regression models to estimate associations between individual, interpersonal/community, and structural/institutional-level factors and either self-reported or LFA-assessed adherence. Overall, 746 HIV-negative FSWs aged 18-40 participated in the study, of whom 180 (24.1%) self-reported currently taking oral-PrEP. Of these, 56 (31.1%) were adherent to oral-PrEP as measured by LFA. In the multivariable analyses, associations with currently taking oral-PrEP included having completed secondary education, high alcohol/substance use, feeling empowered to use PrEP, current intimate partner, no recent intimate partner violence, having support from sex worker organisations, experiencing sex work-related stigma, and seeking healthcare services despite stigma. Associations with oral-PrEP LFA-measured adherence measured included having only primary education, experience of childhood emotional violence, belonging to a higher wealth tertile, and being nulliparous. Oral-PrEP adherence, measured by self-report or objectively, is low among FSWs in Nairobi. Programs to improve oral-PrEP usage among FSWs should work to mitigate social and structural barriers and involve collaboration between FSWs, healthcare providers and policymakers.

Indexed as

Anti-HIV AgentsDrug MonitoringHIV InfectionsPre-Exposure ProphylaxisSelf ReportSex WorkersTenofovirAdministration, OralAdolescentAdultCross-Sectional StudiesFemaleHumansKenyaPoint-of-Care SystemsPoint-of-Care TestingAnti-HIV AgentsTenofovirAdolescent girls and young womenFemale sex workersHierarchical modellingHIV preventionKenyaPrEP

Identifiers

PMID39136824
PMCPMC11471708

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.