Evidence map›Paper›PMID 39136772›Full record

ArticleJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2024

Analyzing the FMN-heme interdomain docking interactions in neuronal and inducible NOS isoforms by pulsed EPR experiments and conformational distribution modeling.

Andrei V Astashkin, Yadav Prasad Gyawali, Ting Jiang, Haikun Zhang, Changjian Feng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Detection of a clamp-shaped conformation of a neuronal nitric oxide synthase construct by pulsed EPR.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Andrei V AstashkinDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, AZ, 85721, USA.
Yadav Prasad GyawaliCollege of Pharmacy, University of New Mexico, Albuquerque, NM, 87131, USA.
Ting JiangCollege of Pharmacy, University of New Mexico, Albuquerque, NM, 87131, USA.
Haikun ZhangCollege of Pharmacy, University of New Mexico, Albuquerque, NM, 87131, USA.
Changjian FengCollege of Pharmacy, University of New Mexico, Albuquerque, NM, 87131, USA. cfeng@unm.edu.

Funding

University of New Mexico Center for Metals in Biology and Medicine - equipment supplementP20GM130422 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Sebastian Medina · 2020 to 2026
$20.4M
Pilot Project CoreP30ES032755 · NIEHS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI FENG, CHANGJIAN (JIM) · 2022 to 2025
$5.2M
Defining the conformational control of nitric oxide synthases by a multipronged approachR01GM133973 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI FENG, CHANGJIAN · 2020 to 2023
$1.5M
Division of Molecular and Cellular Biosciences 2041692NIEHS NIH HHS P30 ES032755NIEHS NIH HHS P30ES032755NIGMS NIH HHS GM133973NIGMS NIH HHS P20 GM130422NIGMS NIH HHS P20GM130422NIGMS NIH HHS R01 GM133973
6 · The paper itself

Abstract

Nitric oxide synthases (NOSs), a family of flavo-hemoproteins with relatively rigid domains linked by flexible regions, require optimal FMN domain docking to the heme domain for efficient interdomain electron transfer (IET). To probe the FMN-heme interdomain docking, the magnetic dipole interactions between the FMN semiquinone radical (FMNH

Indexed as

Flavin MononucleotideHemeNitric Oxide Synthase Type IIAnimalsElectron Spin Resonance SpectroscopyHumansModels, MolecularMolecular Docking SimulationProtein ConformationProtein DomainsRatsFlavin MononucleotideHemeNitric Oxide Synthase Type IINOS2 protein, humanNos2 protein, ratDockingElectron transferFlavinHemeNitric oxide synthasePulsed EPR

Identifiers

PMID39136772
PMCPMC11390318

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.