Evidence map›Paper›PMID 39136694›Full record

ArticleJournal of medicinal chemistry2024

Pharmacophore Identification and Structure-Activity Relationship Analysis of a Series of Substituted Azaindoles as Inhibitors of

Lori Ferrins, Rosario Diaz, Carlos Cordon-Obras, Domingo Rojas-Barros, Antonio Quotadamo, Daniel P Oehme, Gloria Ceballos-Pérez, Uma Swaminathan, Guiomar Pérez-Moreno, Cristina Bosch-Navarrete and 10 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Lori FerrinsDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.ORCID 0000-0001-8992-0919
Rosario DiazInstituto de Parasitología y Biomedicina "López-Neyra" Consejo Superior de Investigaciones Científicas (CSIC), Granada 18100, Spain.
Carlos Cordon-ObrasInstituto de Parasitología y Biomedicina "López-Neyra" Consejo Superior de Investigaciones Científicas (CSIC), Granada 18100, Spain.
Domingo Rojas-BarrosInstituto de Parasitología y Biomedicina "López-Neyra" Consejo Superior de Investigaciones Científicas (CSIC), Granada 18100, Spain.
Antonio QuotadamoDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
Daniel P OehmeDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.ORCID 0000-0002-0291-4856
Gloria Ceballos-PérezInstituto de Parasitología y Biomedicina "López-Neyra" Consejo Superior de Investigaciones Científicas (CSIC), Granada 18100, Spain.
Uma SwaminathanDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
Guiomar Pérez-MorenoInstituto de Parasitología y Biomedicina "López-Neyra" Consejo Superior de Investigaciones Científicas (CSIC), Granada 18100, Spain.
Cristina Bosch-NavarreteInstituto de Parasitología y Biomedicina "López-Neyra" Consejo Superior de Investigaciones Científicas (CSIC), Granada 18100, Spain.
Raquel García-HernándezInstituto de Parasitología y Biomedicina "López-Neyra" Consejo Superior de Investigaciones Científicas (CSIC), Granada 18100, Spain.
Claudia Gomez-LiñanInstituto de Parasitología y Biomedicina "López-Neyra" Consejo Superior de Investigaciones Científicas (CSIC), Granada 18100, Spain.
Andreu SauraInstituto de Parasitología y Biomedicina "López-Neyra" Consejo Superior de Investigaciones Científicas (CSIC), Granada 18100, Spain.
Luis Miguel Ruiz-PerezInstituto de Parasitología y Biomedicina "López-Neyra" Consejo Superior de Investigaciones Científicas (CSIC), Granada 18100, Spain.
Francisco GamarroInstituto de Parasitología y Biomedicina "López-Neyra" Consejo Superior de Investigaciones Científicas (CSIC), Granada 18100, Spain.
Maria Santos Martinez-MartinezTres Cantos R&D Center, GSK, Tres Cantos 28760, Spain.
Pilar ManzanoTres Cantos R&D Center, GSK, Tres Cantos 28760, Spain.
Dolores González-PacanowskaInstituto de Parasitología y Biomedicina "López-Neyra" Consejo Superior de Investigaciones Científicas (CSIC), Granada 18100, Spain.ORCID 0000-0002-4303-5209
Miguel NavarroInstituto de Parasitología y Biomedicina "López-Neyra" Consejo Superior de Investigaciones Científicas (CSIC), Granada 18100, Spain.
Michael P PollastriDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.ORCID 0000-0001-9943-7197

Funding

Optimization and Modes of Action of NEU-4438, a New Anti-trypanosome Lead DrugR01AI124046 · NIAID · NORTHEASTERN UNIVERSITY · PI FERRINS, LORI, MENSA-WILMOT, KOJO A. · 2016 to 2025
$6.0M
Repurposing human kinase inhibitor chemotypes for Neglected Tropical DiseasesR01AI114685 · NIAID · NORTHEASTERN UNIVERSITY · PI FERRINS, LORI · 2015 to 2025
$4.6M
Lead optimization of agents targeting multiple kinetoplastid parasitesR21AI127594 · NIAID · NORTHEASTERN UNIVERSITY · PI POLLASTRI, MICHAEL P · 2017 to 2018
$427k
NIAID NIH HHS R01 AI114685NIAID NIH HHS R01 AI124046NIAID NIH HHS R21 AI127594
6 · The paper itself

Abstract

Human African trypanosomiasis is among the World Health Organization's designated neglected tropical diseases. Repurposing strategies are often employed in academic drug discovery programs due to financial limitations, and in this instance, we used human kinase inhibitor chemotypes to identify substituted 4-aminoazaindoles, exemplified by

Indexed as

IndolesTrypanocidal AgentsTrypanosoma brucei bruceiAnimalsAza CompoundsHumansMiceMolecular StructurePharmacophoreStructure-Activity RelationshipTrypanosomiasis, AfricanAza CompoundsIndolesTrypanocidal Agents

Identifiers

PMID39136694
PMCPMC11345823

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.