ArticleRadiology2024
Quantification of Aortic Valve Fibrotic and Calcific Tissue from CTA: Prospective Comparison with Histology.
Abstract readComparative StudyMulticenter Study
In one paragraph
Article in Radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- One-Click CT-Based Pipeline for Regional Quantification of Aortic Valve Fibrocalcific Degeneration.Annals of biomedical engineering · 2026Article
- Validation of aortic valve calcification quantification on contrast-enhanced computed tomography against ex vivo gravimetric analysis: comparison of fixed Hounsfield unit thresholds and deep learning segmentation.BMC cardiovascular disorders · 2026Article
- Dual-parameter risk stratification based on device landing zone calcification and aortic annular perimeter for paravalvular regurgitation after self-expanding TAVR.European journal of radiology open · 2026Article
- Strategies for Aortic Root Measurement in Patients Undergoing Surveillance for Thoracic Aortic Disease.Journal of clinical medicine · 2026Article
- Impact of Aortic Valve Calcium Burden on Paravalvular Leak Across Balloon-Expandable and Self-Expanding Valves: Insights from a Large TAVR Cohort.Journal of clinical medicine · 2026Article
- Interplay between parathyroid hormone concentration and valvular and aortic calcifications.Archives of medical science : AMS · 2026Article
- Characterization of Aortic Valve Stenosis by CT Angiography in a Diverse US Cohort.Circulation. Cardiovascular imaging · 2025Article
- Thrombus characterisation and evolution of hypoattenuating leaflet thickening after transcatheter aortic valve implantation.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2025Article
- Prothrombotic States in Transcatheter Heart Valve Leaflet Thrombosis (PROSTHESIS): Rationale and Early Results of the Observational Cohort Study.Journal of cardiovascular development and disease · 2025Article
- Predictive Value of Monocyte-To-Lymphocyte Ratio in Differentiating Heart Failure with Reduced Ejection Fraction in Patients with Severe Aortic Stenosis-A Retrospective Analysis.Journal of clinical medicine · 2024Article
- Preprocedural CT angiography and machine learning for mortality prediction after transcatheter aortic valve replacement.Progress in cardiovascular diseasesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Kajetan GrodeckiFrom the First Department of Cardiology (K.G., J. Kochman, Z.H.) and Department of Pathology (A.C., B.G.), Medical University of Warsaw, Warsaw, Poland; Departments of Biomedical Sciences and Medicine, Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, 116 N Robertson Blvd, Suite 400, Los Angeles, CA 90048 (K.G., J.G., P.J.S., D.D.); Department of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, Poznan, Poland (A.O.W., T.U., B.P., M.J.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J. Kwieciński); Department of Cardiology, Centrum voor Hart- en Vaatziekten, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium (J.G.); Department of Cardiology, Banner University Medical Center, Indianapolis, Ind (B.K.T.); Department of Cardiac Surgery (R.G.) and Division of Cardiology and Structural Heart Diseases (J.N.S., W.W.), Medical University of Silesia, Katowice, Poland; and Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (H.J., R.R.M.).ORCID 0000-0002-0358-5679
Anna Olasińska-WiśniewskaFrom the First Department of Cardiology (K.G., J. Kochman, Z.H.) and Department of Pathology (A.C., B.G.), Medical University of Warsaw, Warsaw, Poland; Departments of Biomedical Sciences and Medicine, Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, 116 N Robertson Blvd, Suite 400, Los Angeles, CA 90048 (K.G., J.G., P.J.S., D.D.); Department of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, Poznan, Poland (A.O.W., T.U., B.P., M.J.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J. Kwieciński); Department of Cardiology, Centrum voor Hart- en Vaatziekten, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium (J.G.); Department of Cardiology, Banner University Medical Center, Indianapolis, Ind (B.K.T.); Department of Cardiac Surgery (R.G.) and Division of Cardiology and Structural Heart Diseases (J.N.S., W.W.), Medical University of Silesia, Katowice, Poland; and Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (H.J., R.R.M.).
Agata CyranFrom the First Department of Cardiology (K.G., J. Kochman, Z.H.) and Department of Pathology (A.C., B.G.), Medical University of Warsaw, Warsaw, Poland; Departments of Biomedical Sciences and Medicine, Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, 116 N Robertson Blvd, Suite 400, Los Angeles, CA 90048 (K.G., J.G., P.J.S., D.D.); Department of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, Poznan, Poland (A.O.W., T.U., B.P., M.J.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J. Kwieciński); Department of Cardiology, Centrum voor Hart- en Vaatziekten, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium (J.G.); Department of Cardiology, Banner University Medical Center, Indianapolis, Ind (B.K.T.); Department of Cardiac Surgery (R.G.) and Division of Cardiology and Structural Heart Diseases (J.N.S., W.W.), Medical University of Silesia, Katowice, Poland; and Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (H.J., R.R.M.).
Tomasz UrbanowiczFrom the First Department of Cardiology (K.G., J. Kochman, Z.H.) and Department of Pathology (A.C., B.G.), Medical University of Warsaw, Warsaw, Poland; Departments of Biomedical Sciences and Medicine, Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, 116 N Robertson Blvd, Suite 400, Los Angeles, CA 90048 (K.G., J.G., P.J.S., D.D.); Department of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, Poznan, Poland (A.O.W., T.U., B.P., M.J.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J. Kwieciński); Department of Cardiology, Centrum voor Hart- en Vaatziekten, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium (J.G.); Department of Cardiology, Banner University Medical Center, Indianapolis, Ind (B.K.T.); Department of Cardiac Surgery (R.G.) and Division of Cardiology and Structural Heart Diseases (J.N.S., W.W.), Medical University of Silesia, Katowice, Poland; and Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (H.J., R.R.M.).
Jacek KwiecińskiFrom the First Department of Cardiology (K.G., J. Kochman, Z.H.) and Department of Pathology (A.C., B.G.), Medical University of Warsaw, Warsaw, Poland; Departments of Biomedical Sciences and Medicine, Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, 116 N Robertson Blvd, Suite 400, Los Angeles, CA 90048 (K.G., J.G., P.J.S., D.D.); Department of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, Poznan, Poland (A.O.W., T.U., B.P., M.J.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J. Kwieciński); Department of Cardiology, Centrum voor Hart- en Vaatziekten, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium (J.G.); Department of Cardiology, Banner University Medical Center, Indianapolis, Ind (B.K.T.); Department of Cardiac Surgery (R.G.) and Division of Cardiology and Structural Heart Diseases (J.N.S., W.W.), Medical University of Silesia, Katowice, Poland; and Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (H.J., R.R.M.).
Jolien GeersFrom the First Department of Cardiology (K.G., J. Kochman, Z.H.) and Department of Pathology (A.C., B.G.), Medical University of Warsaw, Warsaw, Poland; Departments of Biomedical Sciences and Medicine, Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, 116 N Robertson Blvd, Suite 400, Los Angeles, CA 90048 (K.G., J.G., P.J.S., D.D.); Department of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, Poznan, Poland (A.O.W., T.U., B.P., M.J.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J. Kwieciński); Department of Cardiology, Centrum voor Hart- en Vaatziekten, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium (J.G.); Department of Cardiology, Banner University Medical Center, Indianapolis, Ind (B.K.T.); Department of Cardiac Surgery (R.G.) and Division of Cardiology and Structural Heart Diseases (J.N.S., W.W.), Medical University of Silesia, Katowice, Poland; and Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (H.J., R.R.M.).
Balaji K TamarappooFrom the First Department of Cardiology (K.G., J. Kochman, Z.H.) and Department of Pathology (A.C., B.G.), Medical University of Warsaw, Warsaw, Poland; Departments of Biomedical Sciences and Medicine, Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, 116 N Robertson Blvd, Suite 400, Los Angeles, CA 90048 (K.G., J.G., P.J.S., D.D.); Department of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, Poznan, Poland (A.O.W., T.U., B.P., M.J.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J. Kwieciński); Department of Cardiology, Centrum voor Hart- en Vaatziekten, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium (J.G.); Department of Cardiology, Banner University Medical Center, Indianapolis, Ind (B.K.T.); Department of Cardiac Surgery (R.G.) and Division of Cardiology and Structural Heart Diseases (J.N.S., W.W.), Medical University of Silesia, Katowice, Poland; and Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (H.J., R.R.M.).ORCID 0000-0002-8382-4421
Bartłomiej PerekFrom the First Department of Cardiology (K.G., J. Kochman, Z.H.) and Department of Pathology (A.C., B.G.), Medical University of Warsaw, Warsaw, Poland; Departments of Biomedical Sciences and Medicine, Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, 116 N Robertson Blvd, Suite 400, Los Angeles, CA 90048 (K.G., J.G., P.J.S., D.D.); Department of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, Poznan, Poland (A.O.W., T.U., B.P., M.J.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J. Kwieciński); Department of Cardiology, Centrum voor Hart- en Vaatziekten, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium (J.G.); Department of Cardiology, Banner University Medical Center, Indianapolis, Ind (B.K.T.); Department of Cardiac Surgery (R.G.) and Division of Cardiology and Structural Heart Diseases (J.N.S., W.W.), Medical University of Silesia, Katowice, Poland; and Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (H.J., R.R.M.).
Radosław GocołFrom the First Department of Cardiology (K.G., J. Kochman, Z.H.) and Department of Pathology (A.C., B.G.), Medical University of Warsaw, Warsaw, Poland; Departments of Biomedical Sciences and Medicine, Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, 116 N Robertson Blvd, Suite 400, Los Angeles, CA 90048 (K.G., J.G., P.J.S., D.D.); Department of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, Poznan, Poland (A.O.W., T.U., B.P., M.J.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J. Kwieciński); Department of Cardiology, Centrum voor Hart- en Vaatziekten, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium (J.G.); Department of Cardiology, Banner University Medical Center, Indianapolis, Ind (B.K.T.); Department of Cardiac Surgery (R.G.) and Division of Cardiology and Structural Heart Diseases (J.N.S., W.W.), Medical University of Silesia, Katowice, Poland; and Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (H.J., R.R.M.).
Joanna Nawara-SkipirzepaFrom the First Department of Cardiology (K.G., J. Kochman, Z.H.) and Department of Pathology (A.C., B.G.), Medical University of Warsaw, Warsaw, Poland; Departments of Biomedical Sciences and Medicine, Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, 116 N Robertson Blvd, Suite 400, Los Angeles, CA 90048 (K.G., J.G., P.J.S., D.D.); Department of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, Poznan, Poland (A.O.W., T.U., B.P., M.J.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J. Kwieciński); Department of Cardiology, Centrum voor Hart- en Vaatziekten, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium (J.G.); Department of Cardiology, Banner University Medical Center, Indianapolis, Ind (B.K.T.); Department of Cardiac Surgery (R.G.) and Division of Cardiology and Structural Heart Diseases (J.N.S., W.W.), Medical University of Silesia, Katowice, Poland; and Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (H.J., R.R.M.).
Marek JemielityFrom the First Department of Cardiology (K.G., J. Kochman, Z.H.) and Department of Pathology (A.C., B.G.), Medical University of Warsaw, Warsaw, Poland; Departments of Biomedical Sciences and Medicine, Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, 116 N Robertson Blvd, Suite 400, Los Angeles, CA 90048 (K.G., J.G., P.J.S., D.D.); Department of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, Poznan, Poland (A.O.W., T.U., B.P., M.J.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J. Kwieciński); Department of Cardiology, Centrum voor Hart- en Vaatziekten, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium (J.G.); Department of Cardiology, Banner University Medical Center, Indianapolis, Ind (B.K.T.); Department of Cardiac Surgery (R.G.) and Division of Cardiology and Structural Heart Diseases (J.N.S., W.W.), Medical University of Silesia, Katowice, Poland; and Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (H.J., R.R.M.).
Janusz KochmanFrom the First Department of Cardiology (K.G., J. Kochman, Z.H.) and Department of Pathology (A.C., B.G.), Medical University of Warsaw, Warsaw, Poland; Departments of Biomedical Sciences and Medicine, Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, 116 N Robertson Blvd, Suite 400, Los Angeles, CA 90048 (K.G., J.G., P.J.S., D.D.); Department of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, Poznan, Poland (A.O.W., T.U., B.P., M.J.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J. Kwieciński); Department of Cardiology, Centrum voor Hart- en Vaatziekten, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium (J.G.); Department of Cardiology, Banner University Medical Center, Indianapolis, Ind (B.K.T.); Department of Cardiac Surgery (R.G.) and Division of Cardiology and Structural Heart Diseases (J.N.S., W.W.), Medical University of Silesia, Katowice, Poland; and Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (H.J., R.R.M.).
Wojciech WojakowskiFrom the First Department of Cardiology (K.G., J. Kochman, Z.H.) and Department of Pathology (A.C., B.G.), Medical University of Warsaw, Warsaw, Poland; Departments of Biomedical Sciences and Medicine, Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, 116 N Robertson Blvd, Suite 400, Los Angeles, CA 90048 (K.G., J.G., P.J.S., D.D.); Department of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, Poznan, Poland (A.O.W., T.U., B.P., M.J.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J. Kwieciński); Department of Cardiology, Centrum voor Hart- en Vaatziekten, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium (J.G.); Department of Cardiology, Banner University Medical Center, Indianapolis, Ind (B.K.T.); Department of Cardiac Surgery (R.G.) and Division of Cardiology and Structural Heart Diseases (J.N.S., W.W.), Medical University of Silesia, Katowice, Poland; and Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (H.J., R.R.M.).ORCID 0000-0002-3681-5207
Barbara GórnickaFrom the First Department of Cardiology (K.G., J. Kochman, Z.H.) and Department of Pathology (A.C., B.G.), Medical University of Warsaw, Warsaw, Poland; Departments of Biomedical Sciences and Medicine, Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, 116 N Robertson Blvd, Suite 400, Los Angeles, CA 90048 (K.G., J.G., P.J.S., D.D.); Department of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, Poznan, Poland (A.O.W., T.U., B.P., M.J.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J. Kwieciński); Department of Cardiology, Centrum voor Hart- en Vaatziekten, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium (J.G.); Department of Cardiology, Banner University Medical Center, Indianapolis, Ind (B.K.T.); Department of Cardiac Surgery (R.G.) and Division of Cardiology and Structural Heart Diseases (J.N.S., W.W.), Medical University of Silesia, Katowice, Poland; and Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (H.J., R.R.M.).
Piotr J SlomkaFrom the First Department of Cardiology (K.G., J. Kochman, Z.H.) and Department of Pathology (A.C., B.G.), Medical University of Warsaw, Warsaw, Poland; Departments of Biomedical Sciences and Medicine, Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, 116 N Robertson Blvd, Suite 400, Los Angeles, CA 90048 (K.G., J.G., P.J.S., D.D.); Department of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, Poznan, Poland (A.O.W., T.U., B.P., M.J.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J. Kwieciński); Department of Cardiology, Centrum voor Hart- en Vaatziekten, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium (J.G.); Department of Cardiology, Banner University Medical Center, Indianapolis, Ind (B.K.T.); Department of Cardiac Surgery (R.G.) and Division of Cardiology and Structural Heart Diseases (J.N.S., W.W.), Medical University of Silesia, Katowice, Poland; and Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (H.J., R.R.M.).ORCID 0000-0002-6110-938X
Hasan JilaihawiFrom the First Department of Cardiology (K.G., J. Kochman, Z.H.) and Department of Pathology (A.C., B.G.), Medical University of Warsaw, Warsaw, Poland; Departments of Biomedical Sciences and Medicine, Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, 116 N Robertson Blvd, Suite 400, Los Angeles, CA 90048 (K.G., J.G., P.J.S., D.D.); Department of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, Poznan, Poland (A.O.W., T.U., B.P., M.J.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J. Kwieciński); Department of Cardiology, Centrum voor Hart- en Vaatziekten, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium (J.G.); Department of Cardiology, Banner University Medical Center, Indianapolis, Ind (B.K.T.); Department of Cardiac Surgery (R.G.) and Division of Cardiology and Structural Heart Diseases (J.N.S., W.W.), Medical University of Silesia, Katowice, Poland; and Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (H.J., R.R.M.).
Raj R MakkarFrom the First Department of Cardiology (K.G., J. Kochman, Z.H.) and Department of Pathology (A.C., B.G.), Medical University of Warsaw, Warsaw, Poland; Departments of Biomedical Sciences and Medicine, Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, 116 N Robertson Blvd, Suite 400, Los Angeles, CA 90048 (K.G., J.G., P.J.S., D.D.); Department of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, Poznan, Poland (A.O.W., T.U., B.P., M.J.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J. Kwieciński); Department of Cardiology, Centrum voor Hart- en Vaatziekten, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium (J.G.); Department of Cardiology, Banner University Medical Center, Indianapolis, Ind (B.K.T.); Department of Cardiac Surgery (R.G.) and Division of Cardiology and Structural Heart Diseases (J.N.S., W.W.), Medical University of Silesia, Katowice, Poland; and Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (H.J., R.R.M.).
Zenon Huczek *From the First Department of Cardiology (K.G., J. Kochman, Z.H.) and Department of Pathology (A.C., B.G.), Medical University of Warsaw, Warsaw, Poland; Departments of Biomedical Sciences and Medicine, Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, 116 N Robertson Blvd, Suite 400, Los Angeles, CA 90048 (K.G., J.G., P.J.S., D.D.); Department of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, Poznan, Poland (A.O.W., T.U., B.P., M.J.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J. Kwieciński); Department of Cardiology, Centrum voor Hart- en Vaatziekten, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium (J.G.); Department of Cardiology, Banner University Medical Center, Indianapolis, Ind (B.K.T.); Department of Cardiac Surgery (R.G.) and Division of Cardiology and Structural Heart Diseases (J.N.S., W.W.), Medical University of Silesia, Katowice, Poland; and Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (H.J., R.R.M.).
Damini Dey *From the First Department of Cardiology (K.G., J. Kochman, Z.H.) and Department of Pathology (A.C., B.G.), Medical University of Warsaw, Warsaw, Poland; Departments of Biomedical Sciences and Medicine, Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, 116 N Robertson Blvd, Suite 400, Los Angeles, CA 90048 (K.G., J.G., P.J.S., D.D.); Department of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, Poznan, Poland (A.O.W., T.U., B.P., M.J.); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J. Kwieciński); Department of Cardiology, Centrum voor Hart- en Vaatziekten, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium (J.G.); Department of Cardiology, Banner University Medical Center, Indianapolis, Ind (B.K.T.); Department of Cardiac Surgery (R.G.) and Division of Cardiology and Structural Heart Diseases (J.N.S., W.W.), Medical University of Silesia, Katowice, Poland; and Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (H.J., R.R.M.).ORCID 0000-0003-2236-6970
Funding
Integrated prediction of cardiovascular events by automated coronary plaque and pericoronary adipose tissue quantification from CT AngiographyR01HL148787 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI DEY, DAMINI · 2020 to 2023
$3.0MAI-enabled characterization of fibrocalcific aortic valve disease and inflammation from CT Angiography: Patient-specific outcome predictionR01HL175875 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI Damini Dey · 2024 to 2026
$2.4MEffect of Intensive Medical Treatment on Quantified Coronary Artery Plaque Components with Serial Coronary CTA in Women with Non-Obstructive CADR01HL151266 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI DEY, DAMINI, TAMARAPPOO, BALAJI K. · 2020 to 2023
$1.6MNHLBI NIH HHS R01 HL148787NHLBI NIH HHS R01 HL151266NHLBI NIH HHS R01 HL175875
Abstract
Background Quantifying the fibrotic and calcific composition of the aortic valve at CT angiography (CTA) can be useful for assessing disease severity and outcomes of patients with aortic stenosis (AS); however, it has not yet been validated against quantitative histologic findings. Purpose To compare quantification of aortic valve fibrotic and calcific tissue composition at CTA versus histologic examination. Materials and Methods This prospective study included patients who underwent CTA before either surgical aortic valve replacement for AS or orthotopic heart transplant (controls) at two centers between January 2022 and April 2023. At CTA, fibrotic and calcific tissue composition were quantified using automated Gaussian mixture modeling applied to the density of aortic valve tissue components, calculated as [(volume/total tissue volume) × 100]. For histologic evaluation, explanted valve cusps were stained with Movat pentachrome as well as hematoxylin and eosin. For each cusp, three 5-µm slices were obtained. Fibrotic and calcific tissue composition were quantified using a validated artificial intelligence tool and averaged across the aortic valve. Correlations were assessed using the Spearman rank correlation coefficient. Intermodality and interobserver variability were measured using the intraclass correlation coefficient (ICC) and Bland-Altman plots. Results Twenty-nine participants (mean age, 63 years ± 10 [SD]; 23 male) were evaluated: 19 with severe AS, five with moderate AS, and five controls. Fibrocalcific tissue composition strongly correlated with histologic findings (
Indexed as
Aortic ValveAortic Valve StenosisCalcinosisComputed Tomography AngiographyFibrosisAgedFemaleHumansMaleMiddle AgedProspective Studies
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