Evidence map›Paper›PMID 39136508›Full record

ArticleCurrent topics in medicinal chemistry2024

1

Dora C S Costa, Thamires Q Froes, Marina S Mendes, Luana da S M Forezi, Vitor F Ferreira, Marcelo S Castilho, Fernando de C da Silva

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Article in Current topics in medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dora C S CostaDepartamento de Química Orgânica, Universidade Federal Fluminense, Instituto de Química, Niterói, RJ, 24020, 150, Brazil.
Thamires Q FroesPrograma de pós-graduação em Biotecnologia da Universidade Estadual de Feira de Santana, Feira de Santana, BA, Brazil.
Marina S MendesFaculdade de Farmácia da Universidade Federal da Bahia, Bahia, Salvador, BA, Brazil.
Luana da S M ForeziDepartamento de Química Orgânica, Universidade Federal Fluminense, Instituto de Química, Niterói, RJ, 24020, 150, Brazil.
Vitor F FerreiraUniversidade Federal Fluminense, Departamento de Tecnologia Farmacêutica, Faculdade de Farmácia, Niterói, RJ, 24241, 002, Brazil.
Marcelo S CastilhoPrograma de pós-graduação em Biotecnologia da Universidade Estadual de Feira de Santana, Feira de Santana, BA, Brazil.
Fernando de C da SilvaDepartamento de Química Orgânica, Universidade Federal Fluminense, Instituto de Química, Niterói, RJ, 24020, 150, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study investigates the potential of eleven 1H-1,2,3-triazol-1,4-naphthoquinone conjugates as virulence factor inhibitors (like Pyocyanin) and their affinity for PhzM, a crucial enzyme for Pyocyanin biosynthesis in

methodsA straightforward synthetic pathway enabled the production of these compounds, which were characterized and structurally confirmed through spectroscopic analyses. Evaluation of their impact on PhzM thermal stability identified promising candidates for PhzM binders.

resultsConcentration-response behavior elucidated their binding affinity, revealing them as the first reported micromolar affinity ligands for PhzM. Structure-activity relationship analysis emphasized the role of specific molecular moieties in binding affinity modulation, paving the way for future advanced inhibitors' development.

conclusionThese findings highlight the potential of naphthoquinone-triazole derivatives as leads for novel therapeutics against

Indexed as

Anti-Bacterial AgentsMicrobial Sensitivity TestsNaphthoquinonesPseudomonas aeruginosaPyocyanineTriazolesDose-Response Relationship, DrugHumansMolecular StructurePseudomonas InfectionsStructure-Activity Relationship1,4-naphthoquinoneAnti-Bacterial AgentsNaphthoquinonesPyocyanineTriazoles1H-123-Triazol-14-naphthoquinoneNovel inhibitorsP. aeruginosaPhzM binders.PyocyaninSpectroscopic analyses

Identifiers

PMID39136508

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.