Evidence map›Paper›PMID 39136500›Full record

SynthesisJournal of diabetes2024

The efficacy of interventions to prevent type 2 diabetes among women with recent gestational diabetes mellitus-A living systematic review and meta-analysis.

Vivian Y Lee, Mohammad R Monjur, Joseph Alvin Santos, Anushka Patel, Rong Liu, Gian Luca Di Tanna, Yashdeep Gupta, Alpesh Goyal, Saumiyah Ajanthan, Devarsetty Praveen and 3 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of diabetes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Vivian Y LeeThe George Institute for Global Health, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0002-9118-9835
Mohammad R MonjurSouth Eastern Sydney Local Health District, Sydney, New South Wales, Australia.
Joseph Alvin SantosThe George Institute for Global Health, Sydney, New South Wales, Australia.
Anushka PatelThe George Institute for Global Health, Sydney, New South Wales, Australia.
Rong LiuThe George Institute for Global Health, Sydney, New South Wales, Australia.
Gian Luca Di TannaThe George Institute for Global Health, Sydney, New South Wales, Australia.
Yashdeep GuptaDepartment of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India.ORCID https://orcid.org/0000-0002-4345-717X
Alpesh GoyalDepartment of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India.ORCID https://orcid.org/0000-0003-0922-5022
Saumiyah AjanthanRemediumOne, Colombo, Sri Lanka.
Devarsetty PraveenFaculty of Medicine, University of New South Wales, Kensington, New South Wales, Australia.
J K LakshmiFaculty of Medicine, University of New South Wales, Kensington, New South Wales, Australia.
H Asita de SilvaClinical Trials Unit, Department of Pharmacology, Faculty of Medicine, University of Kelaniya, Colombo, Sri Lanka.
Nikhil TandonDepartment of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India.ORCID https://orcid.org/0000-0003-4604-1986

Funding

National Health and Medical Research Council Investigator Grant APP2016801
6 · The paper itself

Abstract

backgroundWhile previously considered a transient condition, with no lasting adverse impact, gestational diabetes mellitus (GDM) is now a well-established risk factor for developing type 2 diabetes mellitus (T2DM). The risk of developing T2DM appears to be particularly high in the first few years after childbirth, providing a compelling case for early intervention. This review provides an up-to-date systematic review and meta-analysis to assess the effectiveness of interventions to reduce incidence of T2DM in women with a recent history of GDM.

methodsThe search was conducted on October 20, 2023 with an annual surveillance planned for the next 5 years to maintain a living systematic review. The inclusion criteria were randomized controlled trials of any type in women within 5 years of GDM-complicated pregnancy that reported outcomes of T2DM diagnosis or measures of dysglycemia with a follow-up of at least 12 months.

resultsSeventeen studies met our inclusion criteria and have been included in this review. There were 3 pharmacological and 14 lifestyle interventions. Intervention was not associated with significant reduction in the primary outcome of T2DM (risk ratio, 0.78; 95% confidence interval [CI]: 0.43-1.41; p = 0.41; I

conclusionThis review provides equivocal evidence about the efficacy of interventions to reduce the risk of T2DM in women within 5 years of GDM-complicated pregnancy and highlights the need for further studies, including pharmacotherapy.

Indexed as

Diabetes, GestationalDiabetes Mellitus, Type 2FemaleHumansHypoglycemic AgentsIncidencePregnancyRandomized Controlled Trials as TopicRisk FactorsHypoglycemic Agentsimpaired glucose tolerancepostpartumprevention

Identifiers

PMID39136500
PMCPMC11320752

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.