Evidence map›Paper›PMID 39136442›Full record

ArticlemBio2024

With age comes resilience: how mitochondrial modulation drives age-associated fluconazole tolerance in

Kyungyoon Yoo, Somanon Bhattacharya, Natalia Kronbauer Oliveira, Nivea Pereira de Sa, Gabriel Soares Matos, Maurizio Del Poeta, Bettina C Fries

Abstract read
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Molecular remodelling ofJournal of medical microbiology · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Mitochondrial cardiolipin sequestration of caspofungin underliesbioRxiv : the preprint server for biology · 2026
    Article
  6. Review
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Kyungyoon YooDepartment of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, USA.ORCID 0000-0002-5223-0882
Somanon BhattacharyaDivision of Infectious Diseases, Department of Medicine, Stony Brook University, Stony Brook, New York, USA.ORCID 0000-0002-8562-3877
Natalia Kronbauer OliveiraDepartment of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, USA.ORCID 0000-0001-5381-0988
Nivea Pereira de SaDepartment of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, USA.ORCID 0000-0003-0901-6909
Gabriel Soares MatosDepartment of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, USA.ORCID 0000-0001-8806-6212
Maurizio Del PoetaDepartment of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, USA.ORCID 0000-0001-8418-3120
Bettina C FriesDepartment of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, USA.ORCID 0000-0002-6847-5518

Funding

Lipid-mediated fungal pathogenesisR01AI125770 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI DEL POETA, MAURIZIO · 2016 to 2025
$6.2M
Investigation on Replicative aging in Cryptococcus neoformans populationsR56AI127704 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI FRIES, BETTINA · 2023 to 2023
$555k
BLRD VA I01 BX002624BLRD VA IK6 BX005386NIAID NIH HHS R01 AI125770NIAID NIH HHS R56 AI127704
6 · The paper itself

Abstract

IMPORTANCE: Infections caused by

Indexed as

Antifungal AgentsCryptococcus neoformansDrug Resistance, FungalFluconazoleMitochondriaReactive Oxygen SpeciesATP-Binding Cassette TransportersCryptococcosisErgosterolGene Expression Regulation, FungalHumansMicrobial Sensitivity TestsAntifungal AgentsATP-Binding Cassette TransportersErgosterolFluconazoleReactive Oxygen SpeciesABC transporterantifungal toleranceCryptococcus neoformansergosterolmitochondriareactive oxygen speciesreplicative aging

Identifiers

PMID39136442
PMCPMC11389405

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.