Evidence map›Paper›PMID 39136363›Full record

Trial reportMovement disorders clinical practice2024

Lateralized Subthalamic Stimulation for Axial Dysfunction in Parkinson's Disease: Exploratory Outcomes and Open-Label Extension.

Karlo J Lizarraga, Bhairavei Gnanamanogaran, Tameem M Al-Ozzi, Melanie Cohn, George Tomlinson, Alexandre Boutet, Gavin J B Elias, Jürgen Germann, Derrick Soh, Suneil K Kalia and 7 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Movement disorders clinical practice, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Karlo J LizarragaThe Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, University Hospital Network and Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada.ORCID https://orcid.org/0000-0001-9766-6252
Bhairavei GnanamanogaranThe Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, University Hospital Network and Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada.
Tameem M Al-OzziUniversity of Toronto, Toronto, ON, Canada.
Melanie CohnKrembil Research Institute, Toronto, ON, Canada.ORCID https://orcid.org/0000-0003-2921-7505
George TomlinsonInstitute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.
Alexandre BoutetDepartment of Psychology, University of Toronto, Toronto, ON, Canada.ORCID https://orcid.org/0000-0001-6942-5195
Gavin J B EliasUniversity Health Network, Toronto, ON, Canada.
Jürgen GermannUniversity Health Network, Toronto, ON, Canada.
Derrick SohThe Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, University Hospital Network and Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada.ORCID https://orcid.org/0000-0003-1328-2775
Suneil K KaliaKrembil Research Institute, Toronto, ON, Canada.
Mojgan HodaieKrembil Research Institute, Toronto, ON, Canada.
Renato P MunhozThe Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, University Hospital Network and Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada.
Connie MarrasThe Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, University Hospital Network and Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada.
William D HutchisonKrembil Research Institute, Toronto, ON, Canada.ORCID https://orcid.org/0000-0002-3866-4940
Andres M LozanoKrembil Research Institute, Toronto, ON, Canada.
Anthony E LangThe Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, University Hospital Network and Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada.ORCID https://orcid.org/0000-0003-1229-3667
Alfonso FasanoThe Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, University Hospital Network and Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada.ORCID https://orcid.org/0000-0001-5346-0180

Funding

Training in Research to Assure Neuroscience Scholars Cultivate Expertise in Notable Disparities Science (TRANSCENDS)R25NS098999 · NINDS · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI BRUCE OVBIAGELE · 2017 to 2026
$2.5M
Enhancing Scientific Inquiry in Clinical Neurosciences Through Methodology TrainiR25NS088248 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COFFEY, CHRISTOPHER S., GUTMANN, LAURIE · 2014 to 2018
$2.3M
Chair in Neuromodulation at the University of Toronto and University Hospital Network, Toronto, Ontario, CanadaCIHR Banting Fellowship #471913Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, University Hospital Network, Toronto, Ontario, CanadaNINDS NIH HHS R25 NS088248NINDS NIH HHS R25 NS098999
6 · The paper itself

Abstract

backgroundA randomized trial suggested that reducing left-sided subthalamic stimulation amplitude could improve axial dysfunction.

objectivesTo explore open-label tolerability and associations between trial outcomes and asymmetry data.

methodsWe collected adverse events in trial participants treated with open-label lateralized settings for ≥3 months. We explored associations between trial outcomes, location of stimulation and motor asymmetry.

results14/17 participants tolerated unilateral amplitude reduction (left-sided = 10, right-sided = 4). Two hundred eighty-four left-sided and 1113 right-sided stimulated voxels were associated with faster gait velocity, 81 left-sided and 22 right-sided stimulated voxels were associated with slower gait velocity. Amplitude reduction contralateral to shorter step length was associated with 2.4-point reduction in axial MDS-UPDRS. Reduction contralateral to longer step length was associated with 10-point increase in MDS-UPDRS.

conclusionsLeft-sided amplitude reduction is potentially more tolerable than right-sided amplitude reduction. Right-sided more than left-sided stimulation could be associated with faster gait velocity. Shortened step length might reflect contralateral overstimulation.

Indexed as

Deep Brain StimulationParkinson DiseaseSubthalamic NucleusAgedFemaleFunctional LateralityGait Disorders, NeurologicHumansMaleMiddle AgedTreatment Outcomeasymmetryaxial motor functiondeep brain stimulationlateralizationParkinson's disease

Identifiers

PMID39136363
PMCPMC11542286

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.