Evidence map›Paper›PMID 39136298›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024

Neuroimaging correlates of Alzheimer's disease biomarker concentrations in a racially diverse high-risk cohort of middle-aged adults.

Maria Misiura, Chinkuli Munkombwe, Kay Igwe, Danielle D Verble, Kelly D S Likos, Lex Minto, Alexandria Bartlett, Henrik Zetterberg, Jessica A Turner, Vonetta M Dotson and 3 more

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Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Maria MisiuraDepartment of Psychology, Georgia State University, Atlanta, Georgia, USA.
Chinkuli MunkombweNeuroscience Institute, Georgia State University, Atlanta, Georgia, USA.
Kay IgweTaub Institute for Research in Alzheimer's Disease and the Aging Brain, Gertrude H. Sergievsky Center, and Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Danielle D VerbleNell Hodgson Woodruff School of Nursing, Emory University, Atlanta, Georgia, USA.
Kelly D S LikosNell Hodgson Woodruff School of Nursing, Emory University, Atlanta, Georgia, USA.
Lex MintoDepartment of Psychology, Georgia State University, Atlanta, Georgia, USA.
Alexandria BartlettDepartment of Psychology, Georgia State University, Atlanta, Georgia, USA.
Henrik ZetterbergThe Sahlgrenska Academy, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Mölndal and Gothenburg, University of Gothenburg, Gothenburg, Sweden.
Jessica A TurnerDepartment of Psychiatry and Mental Health, College of Medicine, Ohio State University, Columbus, Ohio, USA.
Vonetta M DotsonDepartment of Psychology, Georgia State University, Atlanta, Georgia, USA.
Adam M BrickmanTaub Institute for Research in Alzheimer's Disease and the Aging Brain, Gertrude H. Sergievsky Center, and Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
William T HuInstitute for Health, Health Care Policy, and Aging Research, Rutgers University, New Brunswick, New Jersey, USA.
Whitney WhartonNell Hodgson Woodruff School of Nursing, Emory University, Atlanta, Georgia, USA.

Funding

Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Emily S Barrett · 1988 to 2026
$47.4M
CSF, MRI, and PET biomarkers of neuroinflammation in Alzheimer's diseaseR01AG054046 · NIA · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI HU, WILLIAM TZU-LUNG · 2016 to 2020
$3.9M
Role of estradiol and related hormones on inflammation, sleep, and risks for Alzheimer's diseaseR01AG066203 · NIA · EMORY UNIVERSITY · PI HU, WILLIAM TZU-LUNG, WHARTON, WHITNEY LEE · 2019 to 2023
$3.6M
NIA NIH HHS R01 AG054046NIA NIH HHS R01 AG066203NIA NIH HHS R01AG066203NIEHS NIH HHS P30 ES005022
6 · The paper itself

Abstract

introductionIn this study, we investigated biomarkers in a midlife, racially diverse, at-risk cohort to facilitate early identification and intervention. We examined neuroimaging measures, including resting state functional magnetic resonance imaging (fMRI), white matter hyperintensity vo (WMH), and hippocampal volumes, alongside cerebrospinal fluid (CSF) markers.

methodsOur data set included 76 cognitively unimpaired, middle-aged, Black Americans (N = 29, F/M = 17/12) and Non-Hispanic White (N = 47, F/M = 27/20) individuals. We compared cerebrospinal fluid phosphorylated tau141 and amyloid beta (Aβ)42 to fMRI default mode network (DMN) subnetwork connectivity, WMH volumes, and hippocampal volumes.

resultsResults revealed a significant race × Aβ42 interaction in Black Americans: lower Aβ42 was associated with reduced DMN connectivity and increased WMH volumes regions but not in non-Hispanic White individuals. DISCUSSION: Our findings suggest that precuneus DMN connectivity and temporal WMHs may be linked to Alzheimer's disease risk pathology during middle age, particularly in Black Americans. HIGHLIGHTS: Cerebrospinal fluid (CSF) amyloid beta (Aβ)42 relates to precuneus functional connectivity in Black, but not White, Americans. Higher white matter hyperintensity volume relates to lower CSF Aβ42 in Black Americans. Precuneus may be a hub for early Alzheimer's disease pathology changes detected by functional connectivity.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesBlack or African AmericanNeuroimagingtau ProteinsBiomarkersBrainCohort StudiesFemaleHippocampusHumansMagnetic Resonance ImagingMaleMiddle AgedPeptide FragmentsWhiteAmyloid beta-Peptidesamyloid beta-protein (1-42)BiomarkersPeptide Fragmentstau ProteinsAlzheimer's diseasecerebrospinal fluidcerebrovascular diseasefunctional connectivityneuroimaging

Identifiers

PMID39136298
PMCPMC11497767

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.