Evidence map›Paper›PMID 39136245›Full record

ArticleMagnetic resonance in medicine2024

Time-division multiplexing (TDM) sequence removes bias in T

Qiang Liu, Borjan Gagoski, Imam Ahmed Shaik, Carl-Fredrik Westin, Elisabeth A Wilde, Walter Schneider, Berkin Bilgic, William A Grissom, Jon-Fredrik Nielsen, Maxim Zaitsev and 2 more

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Qiang LiuBrigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0009-0007-6818-0115
Borjan GagoskiDepartment of Radiology, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0003-3777-2621
Imam Ahmed ShaikBrigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Carl-Fredrik WestinBrigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Elisabeth A WildeVa Salt Lake City Health Care System, Informatics, Decision-Enhancement and Analytic Sciences Center, Salt Lake City, Utah, USA.
Walter SchneiderUniversity of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Berkin BilgicDepartment of Radiology, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-9080-7865
William A GrissomDepartment of Biomedical Engineering, Case School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Jon-Fredrik NielsenFunctional MRI Laboratory, Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA.
Maxim ZaitsevDivision of Medical Physics, Department of Diagnostic and Interventional Radiology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Yogesh RathiBrigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Lipeng NingBrigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Funding

Next generation in-vivo diffusion imaging at submillimeter resolutionR01MH116173 · NIMH · STANFORD UNIVERSITY · PI Yogesh Rathi, Kawin Setsompop · 2018 to 2026
$6.2M
Mapping the superficial white matter connectome of the human brain using ultra high resolution multi-contrast diffusion MRIR01MH125860 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI MAKRIS, NIKOLAOS, O'DONNELL, LAUREN JEAN · 2021 to 2025
$4.1M
Quantitative Glioblastoma Margin and Infiltration Mapping with Advanced Diffusion-Relaxation MRIR01NS125781 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI ALEXANDRA J GOLBY, Carl-Fredrik Westin · 2022 to 2026
$3.6M
A harmonized vendor-agnostic environment for multi-site functional MRI studiesU24NS120056 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jon-Fredrik Nielsen, Maxim Zaitsev · 2021 to 2026
$3.3M
Harmonizing data acquisition, reconstruction, and analysis for reproducible, cross-vendor, open source MRIR01EB032378 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI BILGIC, BERKIN, RATHI, YOGESH · 2022 to 2025
$2.7M
Mapping of the intrinsic and extrinsic cerebellar connectome at ultra high resolution with expert neuroanatomical curationR01MH132610 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI MAKRIS, NIKOLAOS, O'DONNELL, LAUREN JEAN · 2023 to 2025
$2.6M
Joint structural-and-functional MRI analysis for predicting electroconvulsive therapy response in major depressive disorderK01MH117346 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI NING, LIPENG · 2019 to 2023
$916k
Real-time visualization and precision targeting in transcranial magnetic stimulationR21MH126396 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI NING, LIPENG · 2021 to 2022
$493k
NIBIB NIH HHS R01 EB032378NIMH NIH HHS K01 MH117346NIMH NIH HHS R01 MH116173NIMH NIH HHS R01 MH125860NIMH NIH HHS R01 MH132610NIMH NIH HHS R21 MH126396NINDS NIH HHS R01 NS125781NINDS NIH HHS U24 NS120056U.S. Department of Veterans Affairs 36C24E22C0027
6 · The paper itself

Abstract

purposeTo compare the performance of multi-echo (ME) and time-division multiplexing (TDM) sequences for accelerated relaxation-diffusion MRI (rdMRI) acquisition and to examine their reliability in estimating accurate rdMRI microstructure measures.

methodThe ME, TDM, and the reference single-echo (SE) sequences with six TEs were implemented using Pulseq with single-band (SB) and multi-band 2 (MB2) acceleration factors. On a diffusion phantom, the image intensities of the three sequences were compared, and the differences were quantified using the normalized RMS error (NRMSE). Shinnar-Le Roux (SLR) pulses were implemented for the SB-ME and SB-SE sequences to investigate the impact of slice profiles on ME sequences. For the in-vivo brain scan, besides the image intensity comparison and T

resultsTDM performance was similar to the gold standard SE acquisition, whereas ME showed greater biases (3-4× larger NRMSEs for phantom, 2× for in-vivo). T

conclusionOur analysis demonstrates that TDM provides a more accurate estimation of relaxation-diffusion measurements while accelerating the acquisitions by a factor of 2 to 3.

Indexed as

AlgorithmsBrainDiffusion Magnetic Resonance ImagingImage Processing, Computer-AssistedPhantoms, ImagingAdultFemaleHumansImage Interpretation, Computer-AssistedMaleReproducibility of ResultsdiffusiondMRImultidimensional MRIPulseqrdMRIrelaxometry

Identifiers

PMID39136245
PMCPMC11436305

What OpenQuestion holds

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LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.