Evidence map›Paper›PMID 39136139›Full record

ArticleEuropean journal of neurology2024

Endothelium-related biomarkers and cognitive decline in prevalent hemodialysis patients: A prospective cohort study.

Alexandre Braga Libório, Camila Maroni Marques Freire de Medeiros, Leticia Libório Santos, Luana Silveira de Andrade, Gdayllon Cavalcante Meneses, Alice Maria Costa Martins

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Article in European journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Alexandre Braga LibórioMedical Sciences Postgraduate Program, Universidade de Fortaleza-UNIFOR, Fortaleza, Ceará, Brazil.ORCID 0000-0002-0409-6113
Camila Maroni Marques Freire de MedeirosDepartment of Internal Medicine, Medical School, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Leticia Libório SantosMedical Program, Universidade de Fortaleza-UNIFOR, Fortaleza, Ceará, Brazil.
Luana Silveira de AndradeMedical Program, Universidade de Fortaleza-UNIFOR, Fortaleza, Ceará, Brazil.
Gdayllon Cavalcante MenesesMedical Sciences Postgraduate Program, Department of Internal Medicine, Medical School, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Alice Maria Costa MartinsClinical and Toxicological Analysis Department, School of Pharmacy, Federal University of Ceará, Fortaleza, Ceará, Brazil.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico Grant No: 306377/2022-5
6 · The paper itself

Abstract

introductionCognitive decline is prevalent in maintenance hemodialysis patients. The blood-brain barrier has been implicated in cognitive decline. In this prospective cohort study, we investigated the associations between endothelium-related biomarkers and steeper cognitive decline in this population.

methodsCognitive function was assessed using the Portuguese-adapted Cambridge Cognitive Examination (CAMCOG) with items of the Mini-Mental State Examination (MMSE). Endothelium-related biomarkers included syndecan-1, ICAM-1, VCAM-1 and angiopoietin-2 (AGPT2). Patients were followed up for 4 years, and cognitive assessments were repeated. Multinomial regression analyses were performed to evaluate associations between biomarkers and cognitive decline.

resultsA total of 216 patients completed the test battery at baseline. After 4 years, 102 patients had follow-up data. There was a significant decrease in cognitive function according to the CAMCOG and MMSE scores: a change of -0.39 (95% CI -0.27 to -0.51) and -0.51 (95% CI -0.27 to -0.76) standard deviation (SD) of the baseline scores. Additionally, executive function but not memory significantly decreased. Syndecan-1 level was independently associated with steeper cognitive decline; each increase in the SD of the syndecan-1 level was associated with a decrease in the CAMCOG of 0.20 (95% CI 0.07-0.33) SD from baseline. Syndecan-1 was associated with a steeper decline in MMSE score (β 0.54, 95% CI 0.28-0.81) and executive function (β 0.17, 95% CI 0.02-0.32). Syndecan-1 predicted severe cognitive impairment with an area under the curve for receiver operating characteristic curves of 0.75 (95% CI 0.64-0.83).

conclusionOur findings highlight the potential of syndecan-1, a biomarker of endothelium glycocalyx derangement, as a predictor of steeper cognitive decline in prevalent hemodialysis patients.

Indexed as

Angiopoietin-2BiomarkersCognitive DysfunctionRenal DialysisAgedCohort StudiesEndothelium, VascularFemaleHumansIntercellular Adhesion Molecule-1MaleMental Status and Dementia TestsMiddle AgedProspective StudiesSyndecan-1Vascular Cell Adhesion Molecule-1Angiopoietin-2ANGPT2 protein, humanBiomarkersICAM1 protein, humanIntercellular Adhesion Molecule-1SDC1 protein, humanSyndecan-1Vascular Cell Adhesion Molecule-1cognitionendotheliumhemodialysissyndecan‐1

Identifiers

PMID39136139
PMCPMC11555003

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.