Evidence map›Paper›PMID 39136049›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Surface Acoustic Wave-Enhanced Multi-View Acoustofluidic Rotation Cytometry (MARC) for Pre-Cytopathological Screening.

Xiaoyan Zhang, Povilas Dumčius, Roman Mikhaylov, Jiangfa Qi, Mercedes Stringer, Chao Sun, Van Dien Nguyen, You Zhou, Xianfang Sun, Dongfang Liang and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Xiaoyan ZhangDepartment of Electrical and Electronic Engineering, School of Engineering, Cardiff University, Cardiff, CF24 3AA, UK.
Povilas DumčiusDepartment of Electrical and Electronic Engineering, School of Engineering, Cardiff University, Cardiff, CF24 3AA, UK.
Roman MikhaylovDepartment of Electrical and Electronic Engineering, School of Engineering, Cardiff University, Cardiff, CF24 3AA, UK.
Jiangfa QiInternational Joint Laboratory of Biomedicine and Engineering, College of Biomedicine and Health, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, 430070, P. R. China.
Mercedes StringerDepartment of Electrical and Electronic Engineering, School of Engineering, Cardiff University, Cardiff, CF24 3AA, UK.
Chao SunSchool of Life Sciences, Northwestern Polytechnical University, Xi'an, 710072, P. R. China.
Van Dien NguyenSystems Immunity University Research Institute, Cardiff University, Cardiff, CF14 4XN, UK.
You ZhouSystems Immunity University Research Institute, Cardiff University, Cardiff, CF14 4XN, UK.
Xianfang SunSchool of Computer Science and Informatics, Cardiff University, Cardiff, CF24 4AG, UK.
Dongfang LiangDepartment of Engineering, University of Cambridge, Cambridge, CB2 1PZ, UK.
Dongge LiuDepartment of Pathology, Beijing Hospital, Beijing, 100730, P. R. China.
Bing YanDepartment of Information Management, Beijing Hospital, Beijing, 100730, P. R. China.
Xi FengDepartment of Pathology, Hubei Cancer Hospital, Wuhan, 430079, P. R. China.
Changjun MeiDepartment of Pathology, Xiangzhou District People's Hospital of Xiangyang, Xiangyang, 441000, P. R. China.
Cong XuDepartment of Pathology, Xiangzhou District People's Hospital of Xiangyang, Xiangyang, 441000, P. R. China.
Mingqian FengInternational Joint Laboratory of Biomedicine and Engineering, College of Biomedicine and Health, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, 430070, P. R. China.
Yongqing FuFaculty of Engineering and Environment, Northumbria University, Newcastle Upon Tyne, NE1 8ST, UK.
Aled ClaytonSchool of Medicine, Cardiff University, Cardiff, CF14 4XN, UK.
Ruicong ZhiSchool of Computer and Communication Engineering, University of Science and Technology Beijing, Beijing, 100083, P. R. China.
Liangfei TianDepartment of Biomedical Engineering, MOE Key Laboratory of Biomedical Engineering, Zhejiang University, Hangzhou, 310027, P. R. China.
Zhiqiang DongInternational Joint Laboratory of Biomedicine and Engineering, College of Biomedicine and Health, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, 430070, P. R. China.
Xin YangDepartment of Electrical and Electronic Engineering, School of Engineering, Cardiff University, Cardiff, CF24 3AA, UK.ORCID 0000-0002-8429-7598

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytopathology, crucial in disease diagnosis, commonly uses microscopic slides to scrutinize cellular abnormalities. However, processing high volumes of samples often results in numerous negative diagnoses, consuming significant time and resources in healthcare. To address this challenge, a surface acoustic wave-enhanced multi-view acoustofluidic rotation cytometry (MARC) technique is developed for pre-cytopathological screening. MARC enhances cellular morphology analysis through comprehensive and multi-angle observations and amplifies subtle cell differences, particularly in the nuclear-to-cytoplasmic ratio, across various cell types and between cancerous and normal tissue cells. By prioritizing MARC-screened positive cases, this approach can potentially streamline traditional cytopathology, reducing the workload and resources spent on negative diagnoses. This significant advancement enhances overall diagnostic efficiency, offering a transformative vision for cytopathological screening.

Indexed as

Flow CytometryAcousticsCytodiagnosisHumansSoundacoustofluidicscell nuclearcell rotationcytopathologysurface acoustic wave

Identifiers

PMID39136049
PMCPMC11497091

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.