Evidence map›Paper›PMID 39135937›Full record

ReviewClinical kidney journal2024

Anaemia and quality of life in chronic kidney disease: a consensus document from the European Anaemia of CKD Alliance.

Indranil Dasgupta, Corinne Isnard Bagnis, Matteo Floris, Hans Furuland, Daniel Gallego Zurro, Loreto Gesualdo, Nathalie Heirman, Roberto Minutolo, Antonello Pani, José Portolés and 6 more

Abstract readReview
In one paragraph

Review in Clinical kidney journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  4. Article
  5. Article
  6. Kidney involvement and anemia in COVID-19 infection.World journal of nephrology · 2025
    Review
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  9. Observational
  10. Review
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Indranil DasguptaUniversity Hospitals of Birmingham NHS Foundation Trust, Birmingham, UK.
Corinne Isnard BagnisPitié Salpêtrière Hospital, APHP Sorbonne University, Paris, France.
Matteo FlorisDepartment of Nephrology, Dialysis, and Transplantation, ARNAS G. Brotzu, Cagliari, Italy.
Hans FurulandDepartment of Medical Sciences, Nephrology Unit, Uppsala University Hospital, Uppsala, Sweden.
Daniel Gallego ZurroEuropean Kidney Patient's Federation, Vienna, Austria.
Loreto GesualdoDepartment of Precision and Regenerative Medicine and Ionian Area, Nephrology and Urology Units, University of Bari Aldo Moro, Bari, Italy.
Nathalie HeirmanGSK, Waver, Belgium.
Roberto MinutoloDepartment of Advanced Medical and Surgical Sciences, University of Campania 'Luigi Vanvitelli', Naples, Italy.ORCID https://orcid.org/0000-0001-5686-2089
Antonello PaniDepartment of Nephrology, Dialysis, and Transplantation, ARNAS G. Brotzu, Cagliari, Italy.
José PortolésNephrology Department, University Hospital Puerta de Hierro, Madrid, Spain.
Christian RosenbergerNephrology and Medical Intensive Care, Charité-Universitaetsmedizin Berlin, Berlin, Germany.
José Emilio Sánchez AlvarezUniversity Hospital de Cabueñes, Asturias, Spain.ORCID https://orcid.org/0000-0002-4431-3223
Pablo Ureña TorresDepartment of Nephrology and Dialysis, AURA Saint Ouen-sur-Seine, Paris, France.ORCID https://orcid.org/0000-0001-6757-1906
Raymond C VanholderDepartment of Internal Medicine and Pediatrics, Nephrology Section, University Hospital, Ghent, Belgium.ORCID https://orcid.org/0000-0003-2633-1636
Christoph WannerDepartment of Clinical Research and Epidemiology, Comprehensive Heart Failure Centre, University of Würzburg, Würzburg, Germany.ORCID https://orcid.org/0000-0001-9507-5301
European Anaemia of aCKD Alliance

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anaemia is common in chronic kidney disease (CKD) and has a significant impact on quality of life (QoL), work productivity and outcomes. Current management includes oral or intravenous iron and erythropoiesis-stimulating agents (ESAs), to which hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) have been recently added, increasing the available therapeutic options. In randomised controlled trials, only intravenous iron improved cardiovascular outcome, while some ESAs were associated with increased adverse cardiovascular events. Despite therapeutic advances, several challenges and unmet needs remain in the current management of anaemia of CKD. In particular, clinical practice does not include an assessment of QoL, which prompted a group of European nephrologists and representatives of patient advocacy groups to revisit the current approach. In this consensus document, the authors propose a move towards a more holistic, personalised and long-term approach, based on existing evidence. The focus of treatment should be on improving QoL without increasing the risk of adverse cardiovascular events, and tailoring management strategies to the needs of the individual. In addition, the authors discuss the suitability of a currently available anaemia of CKD-specific health-related QoL measure for inclusion in the routine clinical management of anaemia of CKD. The authors also outline the logistics and challenges of incorporating such a measure into electronic health records and how it may be used to improve QoL for people with anaemia of CKD.

Indexed as

anaemiaCKDdialysisguidelinesquality of life

Identifiers

PMID39135937
PMCPMC11318044

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.