Evidence map›Paper›PMID 39135695›Full record

ArticleiMeta2024

The challenge and opportunity of gut microbiota-targeted nanomedicine for colorectal cancer therapy.

Yaohua Wei, Feng Shen, Huidong Song, Ruifang Zhao, Weiyue Feng, Yue Pan, Xiaobo Li, Huanling Yu, Giuseppe Familiari, Michela Relucenti and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iMeta, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

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  10. Progress in interventions for vaginal microecology.Frontiers in cellular and infection microbiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yaohua WeiCAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center of Excellence in Nanoscience, National Center for Nanoscience and Technology Beijing China.
Feng ShenDepartment of Gastroenterology and Endoscopy, Xinhua Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Huidong SongGuangzhou Twelfth People's Hospital Guangzhou China.
Ruifang ZhaoCAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center of Excellence in Nanoscience, National Center for Nanoscience and Technology Beijing China.
Weiyue FengCAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics Chinese Academy of Sciences (CAS) Beijing China.
Yue PanGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center, Sun Yat-Sen Memorial Hospital Sun Yat-Sen University Guangzhou China.
Xiaobo LiDepartment of Occupational and Environmental Health, School of Public Health Capital Medical University Beijing China.
Huanling YuDepartment of Nutrition & Food Hygiene, School of Public Health Capital Medical University Beijing China.
Giuseppe FamiliariDepartment of Anatomical, Histological, Forensic Medicine and Orthopedic Science Sapienza University of Rome Roma Italia.
Michela RelucentiDepartment of Anatomical, Histological, Forensic Medicine and Orthopedic Science Sapienza University of Rome Roma Italia.
Michael AschnerDepartment of Molecular Pharmacology Albert Einstein College of Medicine Bronx New York State USA.
Hanping ShiDepartment of Gastrointestinal Surgery and Department of Clinical Nutrition, Beijing Shijitan Hospital Capital Medical University Beijing China.
Rui ChenSchool of Public Health Capital Medical University Beijing China.ORCID 0000-0001-9239-0891
Guangjun NieCAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center of Excellence in Nanoscience, National Center for Nanoscience and Technology Beijing China.
Hanqing ChenDepartment of Nutrition & Food Hygiene, School of Public Health Capital Medical University Beijing China.ORCID 0000-0001-5442-2071

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut microbiota is an integral component of the colorectal cancer (CRC) microenvironment and is intimately associated with CRC initiation, progression, and therapeutic outcomes. We reviewed recent advancements in utilizing nanotechnology for modulating gut microbiota, discussing strategies and the mechanisms underlying their design. For future nanomedicine design, we propose a 5I principle for individualized nanomedicine in CRC management.

Identifiers

PMID39135695
PMCPMC11316922

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.