Solvent-dependent chemoselective synthesis of different isoquinolinones mediated by the hypervalent iodine(III) reagent PISA.

Ze-Nan Hu, Yan-Hui Wang, Jia-Bing Wu, Ze Chen, Dou Hong, Chi Zhang

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Article in Beilstein journal of organic chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Ze-Nan Hu *State Key Laboratory of Elemento-Organic Chemistry, The Research Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, 94 Weijin Road, Tianjin 300071, P. R. China.

Yan-Hui Wang *State Key Laboratory of Elemento-Organic Chemistry, The Research Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, 94 Weijin Road, Tianjin 300071, P. R. China.

Jia-Bing WuState Key Laboratory of Elemento-Organic Chemistry, The Research Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, 94 Weijin Road, Tianjin 300071, P. R. China.

Ze ChenState Key Laboratory of Elemento-Organic Chemistry, The Research Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, 94 Weijin Road, Tianjin 300071, P. R. China.

Dou HongState Key Laboratory of Elemento-Organic Chemistry, The Research Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, 94 Weijin Road, Tianjin 300071, P. R. China.ORCID https://orcid.org/0000-0002-1431-5068

Chi ZhangState Key Laboratory of Elemento-Organic Chemistry, The Research Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, 94 Weijin Road, Tianjin 300071, P. R. China.ORCID https://orcid.org/0000-0001-9050-076X

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6 · The paper itself

Abstract

Isoquinolinone is an important heterocyclic framework in natural products and biologically active molecules, and the efficient synthesis of this structural motif has received much attention in recent years. Herein, we report a (phenyliodonio)sulfamate (PISA)-mediated, solvent-dependent synthesis of different isoquinolinone derivatives. The method provides highly chemoselective access to 3- or 4-substituted isoquinolinone derivatives by reacting

Indexed as

annulationC–H aminationhypervalent iodine reagentiodine(III)isoquinolinonesolvent-dependence

Identifiers

PMID39135661

DOI10.3762/bjoc.20.167

PMCPMC11318619

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