Regioselective alkylation of a versatile indazole: Electrophile scope and mechanistic insights from density functional theory calculations.

Pengcheng Lu, Luis Juarez, Paul A Wiget, Weihe Zhang, Krishnan Raman, Pravin L Kotian

Abstract read

In one paragraph

Article in Beilstein journal of organic chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

Stereospecific Transition-Metal-Free Alkylation of Chiral Non-Racemic Secondary Tosylates with Cyanohydrins: Convenient Access to Enantiomerically Enriched α-Tertiary Ketones.Angewandte Chemie (International ed. in English) · 2026
Article
Recent Advances in the Mitsunobu and Related Reactions: A Review from 2010 to 2024.Topics in current chemistry (Cham) · 2025
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pengcheng Lu *Department of Discovery Chemistry, BioCryst Pharmaceuticals Inc., Discovery Center of Excellence, 2100 Riverchase Center Building 200, Suite 200 Birmingham, AL, 35244, USA.

Luis Juarez *Department of Discovery Chemistry, BioCryst Pharmaceuticals Inc., Discovery Center of Excellence, 2100 Riverchase Center Building 200, Suite 200 Birmingham, AL, 35244, USA.

Paul A WigetDepartment of Discovery Chemistry, BioCryst Pharmaceuticals Inc., Discovery Center of Excellence, 2100 Riverchase Center Building 200, Suite 200 Birmingham, AL, 35244, USA.ORCID https://orcid.org/0000-0002-5407-6188

Weihe ZhangDepartment of Discovery Chemistry, BioCryst Pharmaceuticals Inc., Discovery Center of Excellence, 2100 Riverchase Center Building 200, Suite 200 Birmingham, AL, 35244, USA.ORCID https://orcid.org/0000-0003-2923-9130

Krishnan RamanDepartment of Computational Chemistry and Structural Biology, BioCryst Pharmaceuticals Inc., Discovery Center of Excellence, 2100 Riverchase Center Building 200, Suite 200 Birmingham, AL, 35244, USA.

Pravin L KotianDepartment of Discovery Chemistry, BioCryst Pharmaceuticals Inc., Discovery Center of Excellence, 2100 Riverchase Center Building 200, Suite 200 Birmingham, AL, 35244, USA.ORCID https://orcid.org/0000-0002-3694-6506

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herein, we report a pair of regioselective

Indexed as

DFTindazoleindazole substitutionmechanismN1-substituted indazoleN2-substituted indazoleregioselectivity

Identifiers

PMID39135655

DOI10.3762/bjoc.20.170

PMCPMC11318628

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