ArticleThe Korean journal of internal medicine2024
Obesity is associated with incident chronic kidney disease in individuals with normal renal function.
Article in The Korean journal of internal medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed.
- Article
- Hyperaldosteronism in the Pathophysiology and Management of Cardiovascular-Kidney-Metabolic Syndrome.Diabetes, obesity & metabolism · 2026Review
- Association between healthy lifestyle and risk of chronic kidney disease: a prospective cohort study of 0.5 million Chinese adults.BMC public health · 2026Article
- From bench to bedside: adipose tissue fibrosis in obesity, anti-diabetic therapies, and bariatric surgery.The Korean journal of internal medicine · 2026Review
- Effect of body shape index trajectories on kidney disease incidence and subsequent death in individuals with type 2 diabetes.Diabetology & metabolic syndrome · 2025Article
- Body Mass Index in Late Adolescence and Later Life Kidney Outcomes: A Population-Based Cohort Study in Swedish Men.Kidney medicine · 2025Article
- Obesity and chronic kidney disease, an important piece in the puzzle of Cardiovascular-Kidney- Metabolic syndrome.The Korean journal of internal medicine · 2024Article
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Abstract
BACKGROUND/
aimsObesity has known to be a modifiable risk factor associated with worse outcomes in chronic kidney disease (CKD), but few studies have examined the impact of obesity on CKD incidence in the general population. The purpose of this study was to investigate the role of body mass index (BMI) and waist-to-hip ratio (WHR) as predictors of incident CKD and to evaluate the impact of weight reduction on CKD prevention.
methodsA total of 2,711 participants from a community-based cohort with normal renal function were prospectively analyzed. Among participants with obesity, we analyzed the change in WHR to evaluate the association of obesity reduction with CKD development.
resultsDuring a mean follow-up of 11.03 ± 4.22 years, incident CKD occurred in 190 (7.0%) participants. In the fully adjusted multivariable Cox proportional hazard models, the risk of incident CKD increased with higher BMI (hazard ratio, 1.06; 95% confidence interval, 1.00-1.11; p = 0.033) and higher WHR (hazard ratio, 1.33; 95% confidence interval, 1.07-1.66; p = 0.009). In the Kaplan-Meier analysis, cumulative adverse renal events were significantly more common in the maintained obesity group than in the reduced obesity group (p = 0.001).
conclusionBoth higher BMI and WHR were associated with development of CKD, but the magnitude of the effect of WHR was higher than that of BMI. Moreover, reducing obesity would be beneficial for renal prognosis.
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