Evidence map›Paper›PMID 39135333›Full record

ArticleJournal of clinical periodontology2024

Diabetes mellitus exacerbates inflammation in a murine model of ligature-induced peri-implantitis: A histological and microtomographic study.

Davi N A Silva, Sepehr Monajemzadeh, Maísa Casarin, Jaclyn Chalmers, Jacob Lubben, Clara E Magyar, Sotirios Tetradis, Flavia Q Pirih

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical periodontology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. A mechanically compliant SrTiOMaterials today. Bio · 2026
    Article
  2. Article
  3. Review
  4. Peri-Implant Diseases: The Past, the Present, the Future.Journal of periodontal research · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Davi N A SilvaSection of Periodontics, School of Dentistry, University of California, Los Angeles, California, USA.
Sepehr MonajemzadehSection of Periodontics, School of Dentistry, University of California, Los Angeles, California, USA.
Maísa CasarinSchool of Dentistry, Federal University of Pelotas, Pelotas, Brazil.ORCID 0000-0002-3750-5091
Jaclyn ChalmersSection of Periodontics, School of Dentistry, University of California, Los Angeles, California, USA.
Jacob LubbenSection of Periodontics, School of Dentistry, University of California, Los Angeles, California, USA.
Clara E MagyarDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Sotirios TetradisSection of Oral and Maxillofacial Radiology, University of California, Los Angeles, California, USA.
Flavia Q PirihSection of Periodontics, School of Dentistry, University of California, Los Angeles, California, USA.ORCID 0000-0003-1670-7345

Funding

Genomewide association studies in peri-implant bone lossR21DE031431 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PIRIH, FLAVIA · 2022 to 2023
$429k
NIDCR NIH HHS NIH/NIDCR DE031431NIDCR NIH HHS R21 DE031431
6 · The paper itself

Abstract

aimTo investigate the influence of diabetes mellitus (DM) in a murine model of peri-implantitis (PI). MATERIALS AND

methodsTwenty-seven 4-week-old C57BL/6J male mice had their first and second maxillary left molars extracted. Eight weeks later, one machined implant was placed in each mouse. Four weeks after osseointegration, the mice were divided into three groups: (a) control (C), (b) PI and (c) DM + PI. DM was induced by streptozotocin (STZ) administration. After DM induction, PI was induced using ligatures for 2 weeks. The hemimaxillae were collected for micro-CT and histological analyses. The primary outcomes consisted of linear (mm) and volumetric (mm

resultsGingival tissue oedema was detected in the PI and DM + PI groups. Micro-CT showed significantly increased linear and volumetric bone loss in the DM + PI group compared to the C and PI groups. H&E staining showed greater inflammatory response and bone resorption in the PI and DM + PI groups than in the C group. The DM + PI group had significantly higher osteoclast numbers than the C and PI groups. Picrosirius red stained less for types I and III collagen in the PI and DM + PI groups than in the C group. There was a significant increase in monocyte/macrophage (CD-11b) counts and matrix metalloproteinases (MMP-2 and MMP-8) marker levels and a significant decrease in the matrix metalloproteinases inhibition marker (TIMP-2) levels in the DM + PI group compared to the C and PI groups.

conclusionsDM exacerbates PI-induced soft-tissue inflammation, matrix degradation and bone loss.

Indexed as

Diabetes Mellitus, ExperimentalDisease Models, AnimalMice, Inbred C57BLPeri-ImplantitisX-Ray MicrotomographyAlveolar Bone LossAnimalsInflammationLigationMaleMicediabetes mellitusperi‐implantitisstreptozotocin‐induced diabetes

Identifiers

PMID39135333
PMCPMC11487626

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.