Evidence map›Paper›PMID 39135257›Full record

ReviewInternal medicine (Tokyo, Japan)2025

Primary Aldosteronism and Hypokalemia-induced Rhabdomyolysis in a Patient with Aldosterone-producing Adenoma: A Case Report and Literature Review.

Nobumasa Ohara, Takashi Tani, Kenshi Terajima, Tetsutaro Ozawa, Yuichiro Yoneoka, Hiroki Shimada, Yasuhiro Nakamura, Go Hasegawa, Tsutomu Nishiyama

Abstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nobumasa OharaDepartment of Endocrinology and Metabolism, Uonuma Kikan Hospital, Japan.
Takashi TaniDepartment of Neurology, Uonuma Kikan Hospital, Japan.
Kenshi TerajimaDepartment of Neurology, Uonuma Kikan Hospital, Japan.
Tetsutaro OzawaDepartment of Neurology, Tsubame Rosai Hospital, Japan.
Yuichiro YoneokaDepartment of Neurosurgery, Uonuma Kikan Hospital, Japan.
Hiroki ShimadaDivision of Pathology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Japan.
Yasuhiro NakamuraDivision of Pathology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Japan.
Go HasegawaDepartment of Pathology, Uonuma Kikan Hospital, Japan.
Tsutomu NishiyamaDepartment of Urology, Uonuma Kikan Hospital, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many cases of primary aldosteronism (PA) in patients who developed hypokalemia-induced rhabdomyolysis and underwent adrenalectomy for aldosterone-producing adenoma (APA) have been reported; however, the immunohistopathological and molecular features remain unknown. We herein report the case of a 28-year-old woman with PA who presented with hypokalemia-induced rhabdomyolysis and underwent adrenalectomy for unilateral APA. An immunohistochemical analysis revealed that most adenoma cells were positive for steroidogenic enzymes, including CYP11B2. A genetic analysis revealed a somatic mutation in the KCNJ5. These findings suggest a strong aldosterone production capacity in our patient's adenoma, which was presumably related to her severe hyperaldosteronism and the resultant hypokalemia-induced rhabdomyolysis.

Indexed as

AdenomaAdrenal Cortex NeoplasmsAdrenocortical AdenomaAldosteroneHyperaldosteronismHypokalemiaRhabdomyolysisAdrenalectomyAdultFemaleG Protein-Coupled Inwardly-Rectifying Potassium ChannelsHumansAldosteroneG Protein-Coupled Inwardly-Rectifying Potassium ChannelsKCNJ5 protein, humanadrenalectomyaldosterone-producing adenomahypertensionimmunohistochemistryKCNJ5rhabdomyolysis

Identifiers

PMID39135257
PMCPMC11986306

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.