Evidence map›Paper›PMID 39135252›Full record

ReviewInternal medicine (Tokyo, Japan)2025

Two Cases and a Review of the Literature Regarding Severe Interstitial Lung Disease Induced by Hangeshashinto.

Yasuo Kosugi, Naoya Murakami, Yoichi Muramoto, Tatsuki Karino, Masaki Oshima, Terufumi Kawamoto, Hiroaki Motomura, Shun Nakazawa, Yoshika Koinuma, Shinichi Ohba and 2 more

Abstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yasuo KosugiDepartment of Radiation Oncology, Juntendo University Graduate School of Medicine, Japan.
Naoya MurakamiDepartment of Radiation Oncology, Juntendo University Graduate School of Medicine, Japan.
Yoichi MuramotoDepartment of Radiation Oncology, Juntendo University Graduate School of Medicine, Japan.
Tatsuki KarinoDepartment of Radiation Oncology, Juntendo University Graduate School of Medicine, Japan.
Masaki OshimaDepartment of Radiation Oncology, Juntendo University Graduate School of Medicine, Japan.
Terufumi KawamotoDepartment of Radiation Oncology, Juntendo University Graduate School of Medicine, Japan.
Hiroaki MotomuraDepartment of Respiratory Medicine, Faculty of Medicine, Juntendo University, Japan.
Shun NakazawaDepartment of Respiratory Medicine, Faculty of Medicine, Juntendo University, Japan.
Yoshika KoinumaDepartment of Respiratory Medicine, Faculty of Medicine, Juntendo University, Japan.
Shinichi OhbaDepartment of Otorhinolaryngology, Faculty of Medicine, Juntendo University, Japan.
Fumihiko MatsumotoDepartment of Otorhinolaryngology, Faculty of Medicine, Juntendo University, Japan.
Naoto ShikamaDepartment of Radiation Oncology, Juntendo University Graduate School of Medicine, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hangeshashinto is a traditional Japanese herbal medicine that is widely recognized for its efficacy in relieving mucositis induced by chemotherapy and radiotherapy. We herein present the cases of two patients with head and neck cancer who were clinically diagnosed with severe drug-induced interstitial lung disease (DILD) following Hangeshashinto administration for radiation-induced mucositis. Although Hangeshashinto has beneficial properties, it is also associated with a relatively low incidence of DILD, including some reports of death. To ensure patient safety, greater attention should be paid when prescribing Hangeshashinto, especially for elderly patients with factors predisposing them to develop severe DILD.

Indexed as

Drugs, Chinese HerbalLung Diseases, InterstitialAgedFemaleHead and Neck NeoplasmsHumansMaleMiddle AgedMucositisSeverity of Illness IndexDrugs, Chinese Herbaldrug-induced interstitial lung diseaseHangeshashintoKampo medicinemucositisradiation therapy

Identifiers

PMID39135252
PMCPMC11986299

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.