Evidence map›Paper›PMID 39135249›Full record

ReviewInternal medicine (Tokyo, Japan)2025

Esophageal and Ileal Ulcers Caused by Hydroxycarbamide: A Case Report and Literature Review.

Takumi Inaba, Yu Yamamoto, Kaho Hirayama, Takuma Kobayashi, Naoto Izumi, Hirotsugu Sakamoto, Shuji Hatakeyama, Masami Matsumura

Abstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Takumi InabaDivision of General Internal Medicine, Jichi Medical University Hospital, Japan.
Yu YamamotoDivision of General Internal Medicine, Jichi Medical University Hospital, Japan.
Kaho HirayamaDivision of General Internal Medicine, Jichi Medical University Hospital, Japan.
Takuma KobayashiDivision of Gastroenterology, Department of Medicine, Jichi Medical University, Japan.
Naoto IzumiDivision of Gastroenterology, Department of Medicine, Jichi Medical University, Japan.
Hirotsugu SakamotoDivision of Gastroenterology, Department of Medicine, Jichi Medical University, Japan.
Shuji HatakeyamaDivision of General Internal Medicine, Jichi Medical University Hospital, Japan.
Masami MatsumuraDivision of General Internal Medicine, Jichi Medical University Hospital, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hydroxycarbamide, an antimetabolic agent used to treat myeloproliferative disorders, causes side effects, including myelosuppression, skin ulcers, and oral mucositis. Gastrointestinal ulcers are uncommon, and esophageal ulcers have not been previously reported. We present the case of a 74-year-old woman who developed esophageal and ileal ulcers after hydroxycarbamide treatment. Our case and previous reports suggest that hydroxycarbamide can cause ulcers throughout the gastrointestinal tract, which can improve rapidly after discontinuing medication. When new signs and symptoms occur, drug-induced etiologies should be considered as a potential cause. Timely diagnostic treatment with discontinuation of medication is crucial in such cases.

Indexed as

Esophageal DiseasesHydroxyureaIleal DiseasesUlcerAgedFemaleHumansHydroxyureaesophageal ulcergastrointestinal ulcerhydroxycarbamidehydroxyureamyeloproliferative disorder

Identifiers

PMID39135249
PMCPMC11986305

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.