Evidence map›Paper›PMID 39135148›Full record

ArticleJournal of medical case reports2024

Hepatocellular adenomas with severe intra-abdominal bleeding, related to an underlying coagulation disorder: a case report.

C A J Oudmaijer, J Sprakel, D Sprengers, K A Wiese, N Vogelaar- Tintel, J I Franken, T Terkivatan, R J Porte, J N M IJzermans

Abstract readCase Reports
In one paragraph

Article in Journal of medical case reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

C A J OudmaijerErasmus MC Transplant Institute, Department of Surgery, Division of Hepatobiliary and Transplantation Surgery, University Medical Center Rotterdam, Office RG-220, Dr. Molewaterplein 40, 3015 GD, Rotterdam, the Netherlands. c.oudmaijer@erasmusmc.nl.ORCID http://orcid.org/0000-0003-4852-6514
J SprakelErasmus MC Transplant Institute, Department of Surgery, Division of Hepatobiliary and Transplantation Surgery, University Medical Center Rotterdam, Office RG-220, Dr. Molewaterplein 40, 3015 GD, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0001-8842-7401
D SprengersDepartment of Gastro-Enterology, Division of Hepatology, University Medical Center Rotterdam, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0003-4280-4210
K A WieseDepartment of Radiology, University Medical Center Rotterdam, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0002-4960-656X
N Vogelaar- TintelErasmus MC Transplant Institute, Department of Surgery, Division of Hepatobiliary and Transplantation Surgery, University Medical Center Rotterdam, Office RG-220, Dr. Molewaterplein 40, 3015 GD, Rotterdam, the Netherlands.
J I FrankenErasmus MC Transplant Institute, Department of Surgery, Division of Hepatobiliary and Transplantation Surgery, University Medical Center Rotterdam, Office RG-220, Dr. Molewaterplein 40, 3015 GD, Rotterdam, the Netherlands.
T TerkivatanErasmus MC Transplant Institute, Department of Surgery, Division of Hepatobiliary and Transplantation Surgery, University Medical Center Rotterdam, Office RG-220, Dr. Molewaterplein 40, 3015 GD, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0002-2541-1530
R J PorteErasmus MC Transplant Institute, Department of Surgery, Division of Hepatobiliary and Transplantation Surgery, University Medical Center Rotterdam, Office RG-220, Dr. Molewaterplein 40, 3015 GD, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0003-0538-734X
J N M IJzermansErasmus MC Transplant Institute, Department of Surgery, Division of Hepatobiliary and Transplantation Surgery, University Medical Center Rotterdam, Office RG-220, Dr. Molewaterplein 40, 3015 GD, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0003-3558-1039

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHepatocellular adenoma is a rare benign liver tumor. Typically, hepatocellular adenomas are solitary and are found in young women who use estrogen-containing contraceptives. The occurrence of multiple hepatocellular adenoma has been linked to higher body mass index, and as the prevalence of overweight increases, multiple hepatocellular adenomas are seen more often. An hepatocellular adenoma does not always necessitate treatment, as they can regress under conservative strategies. In incidental cases, an adenoma presents owing to bleeding, which is mostly self-limiting. If it is not, embolization of hepatic involved vessels is indicated. CASE PRESENTATION: In this case report, we discuss a 42-year old Caucasian woman with multiple hepatocellular bleeds, treated by multiple endovascular procedures. After the first embolization of an adenoma in the right liver lobe, a second bleed occurred in the left lobe, necessitating additional endovascular intervention. During admittance, treatment was complicated by pulmonary embolism and a pneumonia. During follow-up, our patient was diagnosed with antiphospholipid syndrome.

conclusionHepatocellular adenoma is a rare diagnosis that requires centralized expertise. This particular case illustrates the complexity of treatment strategies for associated intra-abdominal bleeding and possible complications. Although liver adenoma is often an incidental finding, it can also result in significant morbidity. Centralization of treatment leads to expertise in managing complex treatment strategies.

Indexed as

Adenoma, Liver CellEmbolization, TherapeuticLiver NeoplasmsAdultFemaleHumansPulmonary EmbolismCase reportHepatocellular adenomaIntra-abdominal bleedTreatment strategy

Identifiers

PMID39135148
PMCPMC11321172

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.