Evidence map›Paper›PMID 39135095›Full record

ArticleCancer imaging : the official publication of the International Cancer Imaging Society2024

DCE-CT parameters as new functional imaging biomarkers at baseline and during immune checkpoint inhibitor therapy in patients with lung cancer - a feasibility study.

Michael Brun Andersen, Aska Drljevic-Nielsen, Jeanette Haar Ehlers, Kennet Sønderstgaard Thorup, Anders Ohlhues Baandrup, Majbritt Palne, Finn Rasmussen

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Article in Cancer imaging : the official publication of the International Cancer Imaging Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Michael Brun AndersenDepartment of Radiology, Copenhagen University Hospital, Gentofte, Denmark. Michael.brun.andersen@regionh.dk.ORCID http://orcid.org/0000-0003-4886-5620
Aska Drljevic-NielsenDepartment of Radiology and Oncology, Aarhus University Hospital, Skejby, Denmark.
Jeanette Haar EhlersDepartment of Oncology, Zealand University Hospital, Køge, Denmark.
Kennet Sønderstgaard ThorupDepartment of Radiology, Aarhus University Hospital, Skejby, Denmark.
Anders Ohlhues BaandrupDepartment of Radiology, Zealand University Hospital, Køge, Denmark.
Majbritt PalneDepartment of Radiology, Zealand University Hospital, Køge, Denmark.
Finn RasmussenDepartment of Radiology, Aarhus University Hospital, Skejby, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWith the development of immune checkpoint inhibitors for the treatment of non-small cell lung cancer, the need for new functional imaging techniques and early response assessments has increased to account for new response patterns and the high cost of treatment. The present study was designed to assess the prognostic impact of dynamic contrast-enhanced computed tomography (DCE-CT) on survival outcomes in non-small cell lung cancer patients treated with immune checkpoint inhibitors.

methodsThirty-three patients with inoperable non-small-cell lung cancer treated with immune checkpoint inhibitors were prospectively enrolled for DCE-CT as part of their follow-up. A single target lesion at baseline and subsequent follow-up examinations were enclosed in the DCE-CT. Blood volume deconvolution (BV

resultsHigh baseline Blood Volume (BV

conclusionDCE-CT-identified parameters may serve as potential prognostic biomarkers at baseline and during early treatment in patients with NSCLC treated with immune checkpoint inhibitor therapy.

Indexed as

Carcinoma, Non-Small-Cell LungFeasibility StudiesImmune Checkpoint InhibitorsLung NeoplasmsTomography, X-Ray ComputedAgedAged, 80 and overContrast MediaFemaleHumansMaleMiddle AgedPrognosisProspective StudiesContrast MediaImmune Checkpoint InhibitorsCarcinomaClinical oncologyImmunotherapyNon-small-cell lungSpiral computedThoraxTomography

Identifiers

PMID39135095
PMCPMC11320886

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