Evidence map›Paper›PMID 39135077›Full record

ArticleLaboratory animal research2024

Combined treatment with vitamin C, hydrocortisone and thiamine does not attenuate morbidity and mortality of septic sheep.

Tuvshintugs Baljinnyam, Satoshi Fukuda, Yosuke Niimi, Donald Prough, Perenlei Enkhbaatar

Abstract read
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In one paragraph

Article in Laboratory animal research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tuvshintugs BaljinnyamDepartment of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, USA. tubaljin@utmb.edu.ORCID http://orcid.org/0000-0001-8664-9318
Satoshi FukudaDepartment of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, USA.
Yosuke NiimiDepartment of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, USA.
Donald ProughDepartment of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, USA.
Perenlei EnkhbaatarDepartment of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, USA.

Funding

Etiology of Microvascular Changes in Gram-positive Sepsis: Mechanisms and Therapeutic OptionsR01GM097480 · NIGMS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI ENKHBAATAR, PERENLEI · 2012 to 2022
$2.7M
NIGMS NIH HHS R01 GM097480NIH HHS GM097480
6 · The paper itself

Abstract

backgroundSepsis is associated with a highest mortality rate in the ICU. Present study tests the efficacy of combined therapy with vitamin C, hydrocortisone and thiamine (combined therapy) in the ovine model of sepsis induced by Pseudomonas aeruginosa. In this study, sepsis was induced in sheep by instillation of Pseudomonas aeruginosa (1 × 10

resultsThe survival rate was 16.7% in control and 33.3% in treatment groups. In the control group, mean arterial pressure dropped from 93.6 ± 8.6 to 75.5 ± 9.7 mmHg by 9 h, which was not affected by the combined therapy. Pulmonary dysfunction was not attenuated by the combined therapy either. The combined therapy had no effect on increased extravascular lung water content and fluid effusion into thoracic cavity. The bacterial number in the bronchoalveolar lavage fluid was significantly increased in the treatment group than the control group. The blood bacterial number remained comparable between groups.

conclusionsCombined vitamin C, hydrocortisone, and thiamine did not attenuate severity of ovine sepsis.

Indexed as

Bacterial clearanceHydrocortisoneSepsisThiamineVitamin C

Identifiers

PMID39135077
PMCPMC11318330

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