Observational studyRespiratory research2024
Small airway dysfunction links asthma exacerbations with asthma control and health-related quality of life.
Observational study in Respiratory research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed.
- Small airway dysfunction as a functional barrier to spirometry-defined clinical remission in severe asthma treated with biologic therapies.The World Allergy Organization journal · 2026Article
- Small Airway Function as an Indicator for Persistent Airflow Limitation Asthma: A Retrospective Study.The clinical respiratory journal · 2026Article
- Small airway dysfunction: a shared, early, measurable, and potentially treatable trait across COPD, asthma, and fibrotic lung disease.Frontiers in medicine · 2026Review
- Psychological predictors of functioning in patients with asthma.Frontiers in public health · 2026Article
- Dupilumab Treatment is Associated with Improvement in Small Airway Dysfunction in Children with Moderate to Severe Asthma: A Retrospective Analysis.Journal of asthma and allergy · 2026Article
- Real-World Effectiveness and Safety of Single Inhaler Triple Therapy with Beclometasone/ Formoterol/ Glycopyrronium in Moderate to Severe Asthma: TriMaximize Study.Journal of asthma and allergy · 2026Article
- Association between impulse oscillometry Z-scores and asthma control and exacerbation risk in a tertiary severe asthma clinic.Frontiers in allergy · 2026Article
- Analyzing soluble and lung smooth muscle laminin isoform expression in guinea pigs exhibiting various allergic response phenotypes.Frontiers in immunology · 2026Article
- BetaFrontiers in medicine · 2026Review
- Increased risk of acute exacerbation in obstructive airway disease: the impact of metabolic dysfunction-associated steatotic liver disease and small airway dysfunction.BMJ open respiratory research · 2025Article
- Protocol for differentiating primary human small airway epithelial cells at the air-liquid interface.American journal of physiology. Lung cellular and molecular physiology · 2025Article
- Role of impulse oscillometry in chronic obstructive pulmonary disease and asthma-chronic obstructive pulmonary disease overlap.Clinical and translational allergy · 2025Article
- Development and validation of a nomogram for predicting cough variant asthma diagnosis.BMC pulmonary medicine · 2025Article
- Altered actin isoforms expression and enhanced airway responsiveness in asthma: the crucial role of β-cytoplasmic actin.Frontiers in physiology · 2025Article
- Prevalence and Risk Factors of Spirometry-Defined Small Airway Dysfunction in the High-Risk Population for COPD in Yunnan Province, China: A Population Based Cross-Sectional Study.International journal of chronic obstructive pulmonary disease · 2025Article
- The chronological age at which small airway function starts to decline in a healthy Chinese population: a cross-sectional study.Frontiers in allergy · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundSmall airway dysfunction not only affects asthma control, but also has adverse effects on the psychological and/or social activities of asthma patients. However, few long-term observational studies have explored the complex relationship between small airway dysfunction and asthma control and health-related quality of life in patients with asthma exacerbations.
methodsThe study recruited 223 patients with exacerbations of asthma (i.e. those with at least one asthma attack over the past year) and 228 patients without exacerbations of asthma (i.e. those without asthma attacks over the past year). We evaluated SAD in patients with asthma exacerbations using impulse oscillometry method. At each evaluation time point within one year of follow-up, the attending physician conducts a case investigation of the patients. We analyzed the correlation between SAD and general characteristics (age, obesity, smoking history), type 2 inflammation (blood eosinophils, exhaled nitric oxide), FEV
resultsThe SAD prevalence in patients with asthma exacerbation is as high as 75%. SAD is connected with poor asthma control and poor health-related quality of life. The structural equation model indicates that age, obesity, FeNO, and FEV
conclusionsSmall airways are involved from an early stage in asthma. Abnormal function of the small airways can significantly increase airway resistance in asthma patients, while worsening their clinical symptoms. In addition, aging is also a key risk factor for asthma control. Especially, small airway dysfunction links asthma control with health-related quality of life.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.