Evidence map›Paper›PMID 39134901›Full record

ArticleEsophagus : official journal of the Japan Esophageal Society2024

Esophagectomy for esophageal cancer in patients with a history of total pharyngolaryngectomy: a Japanese nationwide retrospective cohort study.

Akihiko Okamura, Masayuki Watanabe, Jun Okui, Kengo Kuriyama, Osamu Shiraishi, Takanori Kurogochi, Tetsuya Abe, Hiroshi Sato, Hiroshi Miyata, Yoshihiko Kawaguchi and 16 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Esophagus : official journal of the Japan Esophageal Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Akihiko Okamura *Department of Esophageal Surgery, Gastroenterology Center, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.
Masayuki WatanabeDepartment of Esophageal Surgery, Gastroenterology Center, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan. masayuki.watanabe@jfcr.or.jp.ORCID 0000-0003-0298-1597
Jun Okui *Department of Preventive Medicine and Public Health, School of Medicine, Keio University, Tokyo, Japan.
Kengo Kuriyama *Department of Esophageal Surgery, Gastroenterology Center, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.
Osamu ShiraishiDepartment of Surgery, Faculty of Medicine, Kindai University, Osaka, Japan.
Takanori KurogochiDivision of Gastrointestinal Surgery, Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.
Tetsuya AbeDepartment of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Aichi, Japan.
Hiroshi SatoDepartment of Gastroenterological Surgery, Saitama Medical University International Medical Center, Saitama, Japan.
Hiroshi MiyataDepartment of Gastroenterological Surgery, Osaka International Cancer Institute, Osaka, Japan.
Yoshihiko KawaguchiFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, Kofu, Yamanashi, Japan.
Yusuke SatoEsophageal Surgery, Akita University Hospital, Akita, Japan.
Hiroaki NaganoDepartment of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan.
Shinsuke TakenoDepartment of Surgery, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Masanobu NakajimaDepartment of Upper Gastrointestinal Surgery, Dokkyo Medical University, Tochigi, Japan.
Kentaro MatsuoDepartment of General and Gastroenterological Surgery, Osaka Medical and Pharmaceutical University, Osaka, Japan.
Kentaro MurakamiDepartment of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.
Katsushi TakebayashiDepartment of Surgery, Shiga University of Medical Science, Otsu, Shiga, Japan.
Sohei MatsumotoDepartment of Surgery, Nara Medical University, Nara, Japan.
Tomoyuki OkumuraDepartment of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan.
Yoshihiro KakejiDivision of Gastrointestinal Surgery, Department of Surgery, Graduate School of Medicine, Kobe University, Kobe, Hyogo, Japan.
Koji KonoDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University, Fukushima, Japan.
Nobuhiko OridateDepartment of Otorhinolaryngology, Head and Neck Surgery, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan.
Yasushi TohDepartment of Gastroenterological Surgery, NHO Kyushu Cancer Center, Fukuoka, Japan.
Hiroya TakeuchiDepartment of Surgery, Hamamatsu University School of Medicine, Shizuoka, Japan.
Yukio KatoriDepartment of Otolaryngology, Head and Neck Surgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Joint Research between the Japan Broncho-esophagological Society and the Japan Esophageal Society

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSecond primary esophageal cancer often develops in patients with head and neck cancer, and esophagectomy in patients with a history of total pharyngolaryngectomy (TPL) is challenging. However, the clinical outcomes of these patients have yet to be examined in a multicenter setting.

methodsWe evaluated the surgical outcomes of a nationwide cohort of 62 patients who underwent esophagectomy for esophageal cancer with a history of TPL.

resultsIvor-Lewis and McKeown esophagectomies were performed in 32 (51.6%) and 30 (48.4%) patients, respectively. Postoperatively, 23 patients (37.1%) developed severe complications, and 7 patients (11.3%) required reoperation within 30 days. Pneumonia and anastomotic leakage occurred in 13 (21.0%) and 16 (25.8%) patients, respectively. Anastomotic leakage occurred more frequently in the McKeown group than in the Ivor-Lewis group (46.7% vs. 6.2%, P < 0.001). The adjusted odds ratio for anastomotic leakage in the McKeown group was 9.64 (95% confidence intervals (CI), 2.11-70.82, P = 0.008). Meanwhile, the 5-year overall survival rates were comparable between the groups (41.8% for Ivor-Lewis and 42.7% for McKeown), and the adjusted hazard ratio of overall survival was 1.44 (95% CI, 0.64-3.29; P = 0.381; Ivor-Lewis as the reference).

conclusionsIn our cohort, anastomotic leakage occurred more frequently after McKeown than Ivor-Lewis esophagectomy, and almost half of patients in the McKeown group experienced leakage. Ivor-Lewis esophagectomy is preferred for decreasing anastomotic leakage when oncologically and technically feasible.

Indexed as

Anastomotic LeakEsophageal NeoplasmsEsophagectomyLaryngectomyPharyngectomyAgedEast Asian PeopleFemaleHumansJapanMaleMiddle AgedNeoplasms, Second PrimaryPneumoniaPostoperative ComplicationsReoperationEsophagectomyIvor-Lewis esophagectomyMcKeown esophagectomyTotal pharyngolaryngectomy

Identifiers

PMID39134901

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.