Evidence map›Paper›PMID 39134830›Full record

ArticleInternational microbiology : the official journal of the Spanish Society for Microbiology2025

Synergistic interaction between Chlorella vulgaris extract and Origanum elongatum essential oil against methicillin-resistant Staphylococcus aureus.

Sanaa Ouzakar, Nadia Skali Senhaji, Abdeltif El Harsal, Jamal Abrini

Abstract read
PubMed Publisher
In one paragraph

Article in International microbiology : the official journal of the Spanish Society for Microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sanaa OuzakarBiotechnology and Applied Microbiology Team, Research Laboratory of Applied Chemistry and Microbiology and Biotechnology, Department of Biology, Faculty of Sciences, Abdelmalek Essaadi University, Tetouan, Morocco. sanaeouzakar@gmail.com.
Nadia Skali SenhajiBiotechnology and Applied Microbiology Team, Research Laboratory of Applied Chemistry and Microbiology and Biotechnology, Department of Biology, Faculty of Sciences, Abdelmalek Essaadi University, Tetouan, Morocco.
Abdeltif El HarsalBiotechnology and Applied Microbiology Team, Research Laboratory of Applied Chemistry and Microbiology and Biotechnology, Department of Biology, Faculty of Sciences, Abdelmalek Essaadi University, Tetouan, Morocco.
Jamal AbriniBiotechnology and Applied Microbiology Team, Research Laboratory of Applied Chemistry and Microbiology and Biotechnology, Department of Biology, Faculty of Sciences, Abdelmalek Essaadi University, Tetouan, Morocco.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The massive emergence of antimicrobial resistance in recent decades has rendered the use of a single-agent strategy ineffective. Consequently, the combination of different therapeutic agents has emerged as a promising new approach. The aim of the present study was to investigate the combined effect of Chlorella vulgaris methanol extract (CVME) and Origanum elongatum essential oil (OEEO) on methicillin-resistant Staphylococcus aureus (MRSA). Thus, the antibacterial activity of OEEO and CVME on Escherichia coli, Staphylococcus aureus, and MRSA was evaluated using the agar well diffusion and broth microdilution methods. The killing activity of CVME and OEEO, individually and in combination, on MRSA ATCC 43300 was tested using the time-kill assay. The synergistic effect was examined by determining the fractional inhibitory concentration index (FICI) using the checkerboard test. The results showed very significant antibacterial activity against all the bacteria tested, for both OEEO and CVME, with minimum inhibitory concentrations (MICs) ranging from 0.125 to 0.25% (v/v) for OEEO and from 3.12 to 6.25 mg mL

Indexed as

Anti-Bacterial AgentsChlorella vulgarisMethicillin-Resistant Staphylococcus aureusOils, VolatileOriganumPlant ExtractsDrug SynergismEscherichia coliMicrobial Sensitivity TestsMicrobial ViabilityAnti-Bacterial AgentsOils, VolatilePlant ExtractsCheckerboard assayChlorella vulgarisMRSAOriganum elongatumSynergyTime-kill assay

Identifiers

PMID39134830

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.