Evidence map›Paper›PMID 39134758›Full record

ArticlePediatric research2025

Quantitative plasma proteomic analysis in children after superior cavopulmonary anastomosis with pulmonary arteriovenous malformations.

Elijah H Bolin, Peter M Mourani, Stephanie D Byrum, Samuel G Mackintosh, Amy M Dossey, Michael J Angtuaco, Dala Zakaria, Lawrence E Greiten, Graham M Strub, Haihong Zhang and 1 more

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Article in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Elijah H BolinDepartment of Pediatrics, Section of Cardiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA. ehbolin@uams.edu.
Peter M MouraniArkansas Children's Research Institute, Little Rock, AR, USA.
Stephanie D ByrumArkansas Children's Research Institute, Little Rock, AR, USA.
Samuel G MackintoshArkansas Children's Research Institute, Little Rock, AR, USA.
Amy M DosseyDepartment of Pediatrics, Section of Cardiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Michael J AngtuacoDepartment of Pediatrics, Section of Cardiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Dala ZakariaDepartment of Pediatrics, Section of Cardiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Lawrence E GreitenArkansas Children's Research Institute, Little Rock, AR, USA.
Graham M StrubArkansas Children's Research Institute, Little Rock, AR, USA.
Haihong ZhangArkansas Children's Research Institute, Little Rock, AR, USA.
Gresham T RichterArkansas Children's Research Institute, Little Rock, AR, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Approximately 1000 children are born every year in the United States with one effective cardiac pumping chamber, or single ventricle heart disease. One of the early causes of mortality in this population is pulmonary arteriovenous malformations (PAVMs), which allow blood to bypass gas exchange in the lungs. PAVMs most frequently occur in children after superior cavopulmonary anastomosis (SCPA), a procedure that redirects venous blood from the upper body to the lungs. Because plasma proteins are in part responsible for directing angiogenesis, we hypothesized that differential protein concentrations would be observed in superior caval blood among children after SCPA according to PAVM status. We performed quantitative plasma proteomics from 11 children with PAVMs and in seven children without PAVMs; an additional 11 children with Fontan circulation were included as a reference. Among children with SCPA, there were no significant differences in the plasma proteomes for those with and without PAVMs. When comparing children with Fontan circulation to those with SCPA and PAVMs, 18 proteins exhibited differential expression (10 downregulated and eight upregulated) in superior caval plasma. These results suggest that factors other than, or in addition to, plasma proteins may be responsible for single ventricle patients' susceptibility to PAVMs after SCPA. IMPACT: What is the key message of your article? We did not identify significant differences in plasma proteins when comparing those children with and without pulmonary arteriovenous malformations (PAVMs) after superior cavopulmonary anastomosis (SCPA). What does it add to the existing literature? The etiology of PAVMs in this population is likely due to factors other than, or in addition to, differences in plasma proteins. What is the impact? Further studies are needed to identify causes of PAVMs among children after SCPA.

Indexed as

Arteriovenous FistulaArteriovenous MalformationsBlood ProteinsFontan ProcedureHeart Bypass, RightProteomeProteomicsPulmonary ArteryPulmonary VeinsChildChild, PreschoolFemaleHeart Defects, CongenitalHumansInfantMaleBlood ProteinsProteome

Identifiers

PMID39134758

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.