Evidence map›Paper›PMID 39134741›Full record

ArticleNature human behaviour2024

Binding of cortical functional modules by synchronous high-frequency oscillations.

Jacob C Garrett, Ilya A Verzhbinsky, Erik Kaestner, Chad Carlson, Werner K Doyle, Orrin Devinsky, Thomas Thesen, Eric Halgren

Abstract read
PubMed Publisher
In one paragraph

Article in Nature human behaviour, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Jacob C GarrettNeurosciences Graduate Program, University of California, San Diego, La Jolla, CA, USA.
Ilya A VerzhbinskyNeurosciences Graduate Program, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-7890-8559
Erik KaestnerCenter for Multimodal Imaging and Genetics, University of California, San Diego, La Jolla, CA, USA.
Chad CarlsonDepartment of Neurology, Medical College of Wisconsin, Milwaukee, WI, USA.
Werner K DoyleDepartment of Neurosurgery, New York University Langone School of Medicine, New York, NY, USA.
Orrin DevinskyDepartment of Neurology, New York University Langone School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-0044-4632
Thomas Thesen *Department of Medical Education, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA.
Eric Halgren *Departments of Radiology and Neurosciences, University of California, San Diego, La Jolla, CA, USA. ehalgren@ucsd.edu.ORCID http://orcid.org/0000-0001-5926-6872

Funding

TRAINING PROGRAM IN COGNITIVE NEUROSCIENCET32MH020002 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SEJNOWSKI, TERRENCE J · 1999 to 2020
$6.1M
From ion channel dynamics to human EEG and MEG: multiscale neuronal models validated by human dataRF1MH117155 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BAZHENOV, MAKSIM V, CASH, SYDNEY S · 2018 to 2018
$3.7M
United States Department of Defense | United States Navy | Office of Naval Research (ONR) N00014-16-1-2829U.S. Department of Health & Human Services | National Institutes of Health (NIH) T32MH020002U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH117155
6 · The paper itself

Abstract

Whether high-frequency phase-locked oscillations facilitate integration ('binding') of information across widespread cortical areas is controversial. Here we show with intracranial electroencephalography that cortico-cortical co-ripples (~100-ms-long ~90 Hz oscillations) increase during reading and semantic decisions, at the times and co-locations when and where binding should occur. Fusiform wordform areas co-ripple with virtually all language areas, maximally from 200 to 400 ms post-word-onset. Semantically specified target words evoke strong co-rippling between wordform, semantic, executive and response areas from 400 to 800 ms, with increased co-rippling between semantic, executive and response areas prior to correct responses. Co-ripples were phase-locked at zero lag over long distances (>12 cm), especially when many areas were co-rippling. General co-activation, indexed by non-oscillatory high gamma, was mainly confined to early latencies in fusiform and earlier visual areas, preceding co-ripples. These findings suggest that widespread synchronous co-ripples may assist the integration of multiple cortical areas for sustained periods during cognition.

Indexed as

Cerebral CortexElectrocorticographyReadingAdultBrain MappingBrain WavesDecision MakingElectroencephalographyFemaleHumansMaleSemanticsYoung Adult

Identifiers

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.