Evidence map›Paper›PMID 39134720›Full record

ArticleSurgical endoscopy2024

Multisociety research collaboration: timing of cholecystectomy following cholecystostomy drainage for acute cholecystitis.

Konstantinos Spaniolas, Aurora Pryor, Dimitrios Stefanidis, Spyridon Giannopoulos, Preston R Miller, Audrey L Spencer, Salvatore Docimo, Christopher DuCoin, Samuel W Ross, Lynnette Schiffern and 10 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Surgical endoscopy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Observational
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Konstantinos SpaniolasDepartment of Surgery, Stony Brook University, Stony Brook, USA. konstantinos.spaniolas@stonybrookmedicine.edu.
Aurora PryorDepartment of Surgery, Northwell Health, New York, USA.
Dimitrios StefanidisDepartment of Surgery, Indiana University, Fort Wayne, USA.
Spyridon GiannopoulosDepartment of Surgery, Indiana University, Fort Wayne, USA.
Preston R MillerDepartment of Surgery, Wake Forest University, Winston-Salem, USA.
Audrey L SpencerDepartment of Surgery, Arizona University, Tucson, USA.
Salvatore DocimoDepartment of Surgery, University of South Florida, Tampa, USA.
Christopher DuCoinDepartment of Surgery, University of South Florida, Tampa, USA.
Samuel W RossDepartment of Surgery, Carolinas Medical Center, Charlotte, USA.
Lynnette SchiffernDepartment of Surgery, Carolinas Medical Center, Charlotte, USA.
Caroline ReinkeDepartment of Surgery, Carolinas Medical Center, Charlotte, USA.
William SherrillDepartment of Surgery, Carolinas Medical Center, Charlotte, USA.
Jeffry NahmiasDepartment of Surgery, UCI School of Medicine, Irvine, USA.
Morgan ManasaDepartment of Surgery, UCI School of Medicine, Irvine, USA.
Tammy KindelDepartment of Surgery, Medical College of Wisconsin, Milwaukee, USA.
Deemantha WijekulasooriyageDepartment of Surgery, Medical College of Wisconsin, Milwaukee, USA.
Luca CardinaliMadonna del Soccorso Hospital, San Benedetto del Tronto, Italy.
Salomone Di SaverioMadonna del Soccorso Hospital, San Benedetto del Tronto, Italy.
Jie YangDepartment of Medicine, Stony Brook University, Stony Brook, USA.
Yunhan LiaoDepartment of Medicine, Stony Brook University, Stony Brook, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with acute cholecystitis (AC) presenting with unfavorable systemic or local conditions are often managed with percutaneous cholecystostomy (PC) as a temporary measure. The clinical outcomes of interval cholecystectomy following PC remain unclear. The aim of the study was to identify the association between the timing of cholecystectomy following PC for AC and perioperative complication rates at interval cholecystectomy. We hypothesized that there would be a specific time interval to cholecystectomy associated with lower risk for adverse events.

methodsThis was a retrospective (2018-2020) multicenter study at 8 participating hospital systems of adult patients with AC, managed with PC and interval cholecystectomy. Demographics, comorbidities, treatment details, and outcomes were examined. Patients were grouped based on quartiles for timing of surgery after PC (< 7, 7-9, 10-13, > 13 weeks). The primary outcome was a composite endpoint of bile duct injury, reoperation, readmission, image-guided intervention, endoscopic intervention, conversion to open surgery, or death.

resultsThere were 188 patients with a median age of 66 years with AC classified as mild (41%), moderate (47%), and severe (12%). Median days from PC to surgery were 65 (Q1 = 48, Q3 = 91). Laparoscopic cholecystectomy (89.9%) was the most commonly planned approach (robotic 6.4%, 3.7% open) and 28 (14.9%) were converted to open. The composite endpoint was reported in 51 patients (27.1%). A biliary injury occurred in 7 (3.7%) patients. Time to surgery and intraoperative drain placement were independently associated with the composite outcome. Cholecystectomy within 7 weeks of PC was associated with decreased risk (OR = 0.36, 95% CI 0.13-0.97) of the composite endpoint, compared to patients undergoing surgery > 13 weeks after PC.

conclusionTiming of surgery following PC was associated with procedural outcomes. Patients undergoing surgery before 7 weeks experienced significantly less morbidity than patients having delayed cholecystectomy. These results should be considered in patient selection and management after PC.

Indexed as

CholecystectomyCholecystitis, AcuteCholecystostomyDrainageTime-to-TreatmentAgedConversion to Open SurgeryFemaleHumansMaleMiddle AgedPostoperative ComplicationsRetrospective StudiesTime FactorsTreatment OutcomeAcute cholecystitisCholecystectomyCholecystostomyInterval cholecystectomy

Identifiers

PMID39134720

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.