ArticleScientific reports2024
An explorative analysis on the optimal cryo-passes and freezing time of the ultrathin cryoprobe in endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Ultrasound-guided transbronchial cryobiopsy of mediastinal and hilar lesions: a multicenter pragmatic cohort study with real-world evidence.BMJ open respiratory research · 2024Trial
- Transbronchial Mediastinal Cryobiopsy-Rising to the Challenge.Respirology (Carlton, Vic.) · 2026Article
- Enhancing Diagnostic Yield: The Role of Endobronchial Ultrasound-Guided Cryobiopsy in the Evaluation of Mediastinal Lymphadenopathy.CHEST pulmonary · 2026Article
- Diagnostic value of EBUS-guided transbronchial mediastinal cryobiopsyERJ open research · 2026Article
- A novel technique using diode laser-assisted endobronchial ultrasound-guided transbronchial biopsy: a brief report.Journal of thoracic disease · 2026Article
- Confocal laser endomicroscopy-assisted endobronchial ultrasound-guided needle aspiration in diagnosing mediastinal and/or hilar lymphadenopathy (COLLABORATION-III): protocol for a randomised controlled trial.BMJ open respiratory research · 2026Article
- Superior Diagnostic Yield of EBUS-Guided Cryobiopsy over Needle Aspiration in Isolated, Mass-Negative Mediastinal Lymphadenopathy: A Prospective Within-Patient Study.Diagnostics (Basel, Switzerland) · 2026Article
- Diagnostic yield and histopathological assessment of endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy: a prospective comparison of two tunnelling approaches.ERJ open research · 2026Article
- Diagnostic Value of EBUS-guided Transbronchial MEdiastinal Cryobiopsy versus ConvenTIONal Bronchoscopic Approaches for Intrathoracic Stage I/II SARcoidosis: protocol for a randomised controlled trial (DETECTION-SAR-II).BMJ open respiratory research · 2026Article
- Convex-probe endobronchial ultrasound-guided cryobiopsy for pleural tumors: three case reports.Translational lung cancer research · 2026Article
- Isolated Mediastinal and Hilar Lymphadenopathy as a Manifestation of IgG4-Related Disease Diagnosed by EBUS-Guided Transbronchial Mediastinal Cryobiopsy.Respirology case reports · 2026Article
- Validation of a modified oxygen nebulized inhalation method in airway surface anesthesia by comparative analysis via scalable broad learning.Scientific reports · 2025Article
- Transbronchial Mediastinal Cryobiopsy Diagnostic Yield and Perioperative Patient Management: A Single Tertiary Center Experience.Thoracic research and practice · 2025Article
- Reply to LeeAmerican journal of respiratory and critical care medicine · 2025Article
- Endobronchial ultrasound-guided transbronchial cryobiopsy through a working channel potentially improving safety and efficacy.Respiratory medicine case reports · 2025Article
- Performance of Endobronchial Ultrasound-Guided Cryobiopsy in Diagnosing Thoracic Disorders and Its Role in Next-Generation Sequencing for Non-Small-Cell Lung Cancer.Pulmonary medicine · 2025Article
- Endobronchial ultrasound-guided transbronchial mediastinal cryobiopsyEndoscopic ultrasoundArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
EBUS-guided transbronchial mediastinal cryobiopsy (TBMC) has emerged as a promising biopsy tool for diagnosing hilar and mediastinal pathologies. However, several fundamental technical aspects of TBMC remain unexplored. This study aims to determine the optimal number of cryo-passes and freezing time of the ultrathin cryoprobe in EBUS-TBMC concerning specimen size and procedural diagnostic yield. We conducted a retrospective chart review of patients with mediastinal and hilar lesions who underwent EBUS-TBMC between January 2021 and April 2023 across three hospitals in Malaysia. A total of 129 EBUS-TBMC procedures were successfully completed, achieving an overall diagnostic yield of 88.4%. Conclusive TBMC procedures were associated with larger specimen sizes (7.0 vs. 5.0 mm, p < 0.01). Specimen size demonstrated a positive correlation with diagnostic yield (p < 0.01), plateauing at specimen size of 4.1-6.0 mm. A significant positive correlation was also observed between the number of cryo-passes and both specimen size (p < 0.01) and diagnostic yield (p < 0.05). Diagnostic yield plateaued after 2-3 cryo-passes. In contrast, longer freezing times trended towards smaller specimens and lower diagnostic yield, though not reaching statistical significance. The highest diagnostic yield was recorded at the 3.1-4.0 s freezing time. The safety profile of TBMC remains favourable, with one case (0.8%) of pneumothorax and nine cases (7%) of self-limiting bleeding. In our cohort, TBMC performance with 2-3 cryo-passes and a 3.1-4.0 s freezing time to achieve a total aggregate specimen size of 4.1-6.0 mm appeared optimal. Further prospective studies are needed to validate these findings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.