ArticleScientific reports2024
Refining pain management in mice by comparing multimodal analgesia and NSAID monotherapy for neurosurgical procedures.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Activity as a readout parameter for neurobehavioral research and severity assessment in laboratory rodents: a systematic comparison and meta-analysis of measurement techniques.Scientific reports · 2026Pooled it
- The Predictive Accuracy of Methods Commonly Used for Evaluating Animal Distress.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Carprofen and buprenorphine delivery using micropipette-guided drug administration (MDA) in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- GrimACE: automated, multimodal cage-side assessment of pain and well-being in mice.Lab animal · 2026Article
- Hydrogel Microneedle Array-Based Transdermal Dressing System for Multiplexed Assessment and Intelligent Therapy of Chronic Wounds.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Challenges and expectations on the use of automated home cage monitoring for advancing laboratory animal care and welfare.Laboratory animals · 2026Article
- Post-operative pain and patient satisfaction after multimodal analgesia: Questionnaire-based chart review.Bioinformation · 2026Article
- Refining humane endpoint detection by time-series forecasting and threshold definition using a multivariate severity score.Frontiers in physiology · 2026Article
- Mechanically Induced Pulpitis: A Rat Model That Preserves Animal Well-Being.Biomedicines · 2025Article
- Testing perioperative meloxicam analgesia to enhance welfare while preserving model validity in an inflammation-induced seizure model.Scientific reports · 2024Article
- A Retrospective Report of Carprofen Administration as Post-Operative Analgesia Reveals Negative Effects of Recommended Doses.Animals : an open access journal from MDPI · 2024Article
- Subcutaneous and orally self-administered high-dose carprofen shows favorable pharmacokinetic and tolerability profiles in male and female C57BL/6J mice.Frontiers in veterinary science · 2024Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
While neurosurgical interventions are frequently used in laboratory mice, refinement efforts to optimize analgesic management based on multimodal approaches appear to be rather limited. Therefore, we compared the efficacy and tolerability of combinations of the non-steroidal anti-inflammatory drug carprofen, a sustained-release formulation of the opioid buprenorphine, and the local anesthetic bupivacaine with carprofen monotherapy. Female and male C57BL/6J mice were subjected to isoflurane anesthesia and an intracranial electrode implant procedure. Given the multidimensional nature of postsurgical pain and distress, various physiological, behavioral, and biochemical parameters were applied for their assessment. The analysis revealed alterations in Neuro scores, home cage locomotion, body weight, nest building, mouse grimace scales, and fecal corticosterone metabolites. A composite measure scheme allowed the allocation of individual mice to severity classes. The comparison between groups failed to indicate the superiority of multimodal regimens over high-dose NSAID monotherapy. In conclusion, our findings confirmed the informative value of various parameters for assessment of pain and distress following neurosurgical procedures in mice. While all drug regimens were well tolerated in control mice, our data suggest that the total drug load should be carefully considered for perioperative management. Future studies would be of interest to assess potential synergies of drug combinations with lower doses of carprofen.
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Registered trials
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