Evidence map›Paper›PMID 39134419›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2024

Amyloid-β Causes NMDA Receptor Dysfunction and Dendritic Spine Loss through mGluR1 and AKAP150-Anchored Calcineurin Signaling.

Olga Prikhodko, Ronald K Freund, Emily Sullivan, Matthew J Kennedy, Mark L Dell'Acqua

Abstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Olga PrikhodkoDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045.
Ronald K FreundDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045.ORCID 0000-0002-1850-1730
Emily SullivanDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045.
Matthew J KennedyDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045 mark.dellacqua@cuanschutz.edu matthew.kennedy@cuanschutz.edu.
Mark L Dell'AcquaDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045 mark.dellacqua@cuanschutz.edu matthew.kennedy@cuanschutz.edu.ORCID 0000-0003-3798-3461

Funding

Regulation of Calcium-permeable AMPA Receptors by AKAP79 Postsynaptic SignalingR01NS040701 · NINDS · UNIVERSITY OF COLORADO DENVER · PI DELL'ACQUA, MARK L · 2001 to 2023
$7.7M
Postsynaptic kinase/phosphatase networks in amyloid beta-induced synaptic dysfunctionR01NS110383 · NINDS · UNIVERSITY OF COLORADO DENVER · PI MARK L DELL'ACQUA, Matthew J Kennedy · 2018 to 2026
$5.2M
Novel approaches for interrogating and manipulating synaptic function, structure and plasticityR35NS116879 · NINDS · UNIVERSITY OF COLORADO DENVER · PI Matthew J Kennedy · 2020 to 2026
$4.0M
Calcineurin activation and scaffolding in A Beta-induced synaptic dysfunctionF32AG071073 · NIA · UNIVERSITY OF COLORADO DENVER · PI PRIKHODKO, OLGA · 2021 to 2023
$210k
NIA NIH HHS F32 AG071073NINDS NIH HHS R01 NS040701NINDS NIH HHS R01 NS110383NINDS NIH HHS R35 NS116879
6 · The paper itself

Abstract

Neuronal excitatory synapses are primarily located on small dendritic protrusions called spines. During synaptic plasticity underlying learning and memory, Ca

Indexed as

A Kinase Anchor ProteinsAmyloid beta-PeptidesCalcineurinDendritic SpinesReceptors, Metabotropic GlutamateReceptors, N-Methyl-D-AspartateSignal TransductionAnimalsFemaleHippocampusLong-Term Synaptic DepressionMaleMiceMice, Inbred C57BLMice, TransgenicAkap5 protein, mouseA Kinase Anchor ProteinsAmyloid beta-PeptidesCalcineurinmetabotropic glutamate receptor type 1Receptors, Metabotropic GlutamateReceptors, N-Methyl-D-AspartateAKAPamyloid-βcalcineurindendritic spinemGluR1NMDA receptor

Identifiers

PMID39134419
PMCPMC11391497

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.