ArticleAJNR. American journal of neuroradiology2025
Hemodynamic Characteristics in Ruptured and Unruptured Intracranial Aneurysms: A Prospective Cohort Study Utilizing the AneurysmFlow Tool.
Article in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Comparison of efficacy and safety between Neuroform Atlas stent-assisted coiling and coiling alone for irregular intracranial aneurysms: a single-center retrospective study.Neurosurgical review · 2026Article
- Atherosclerotic changes of the parent artery associated with ruptures in small (<7 mm) anterior communicating artery aneurysms.Frontiers in neurology · 2026Article
- Management and Outcomes of Multiple Unruptured Cerebral Aneurysms: A Descriptive Cohort Analysis.Brain sciences · 2025Article
- A landmine during cranioplasty: unusual rupture of a previously undiagnosed aneurysm. Illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- A case-control study on blood vessel morphology, hemodynamic parameters, and rupture status of posterior communicating artery aneurysms.Frontiers in neurologyArticle
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Authors and funding
12 authors.
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Abstract
background and purposeHemodynamic factors significantly influence the onset, progression, and rupture of intracranial aneurysms (IAs). Current rupture risk prediction scores focus primarily on the clinical, anatomic, and morphologic aspects. This study aimed to investigate the hemodynamic characteristics differences between ruptured and unruptured IAs. MATERIALS AND
methodsConducted from July 2021 to July 2022, this prospective cohort study involved patients with ruptured and unruptured IAs undergoing DSA. Hemodynamic characteristics were assessed by using the AneurysmFlow tool. Hemodynamic, clinical, anatomic, and morphologic parameters were compared between ruptured and unruptured IA groups.
resultsThe study included 127 patients with 135 aneurysms (67 ruptured, 68 unruptured). Complex flow patterns (type 3 and 4) were observed more frequently in ruptured aneurysms compared with unruptured aneurysms (OR, 5.57; 95% CI, 2.49-12.45;
conclusionsComplex flow patterns identified on the AneurysmFlow tool are significantly more common in ruptured and unruptured aneurysms associated with daughter sac features. The lowest MAFA in the aneurysmal dome and daughter sacs likely indicates specific pathophysiologic changes within the aneurysm wall associated with rupture incidence. Hypertension, bifurcation location, and an irregular shape are independently associated with the risk of rupture. Further multicenter studies with larger sample sizes are needed to validate these findings.
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