SynthesisAJNR. American journal of neuroradiology2025
Clinical Outcome of Pipeline Embolization Device with and without Coils to Treat Intracranial Aneurysm: A Systematic Review and Meta-Analysis.
Synthesis in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Efficacy and safety profiles of single versus multiple pipeline embolization devices for intracranial aneurysms: a systematic review and meta-analysis.Neurosurgical review · 2026Pooled it
- Comparison of the efficacy and safety of flow diversion versus stent-assisted coiling in posterior circulation aneurysms: a systematic review and meta-analysis.Frontiers in neurologyPooled it
- First clinical experience with the surpass elite flow diverter in the treatment of intracranial aneurysms.Neuroradiology · 2026Article
- MRA-based aneurysm occlusion assessment in the early phase after flow diverter treatment: a multicenter retrospective study focusing on the impact of aneurysm diameter.Neurosurgical review · 2026Article
- Gradual Occlusion of an Anterior Choroidal Artery Aneurysm Using Overlapping Flow Diversion and Short-term Anticoagulation: A Case Report.NMC case report journal · 2026Article
- Factors Associated with Aneurysm Occlusion after Flow Diverter Treatment.Journal of neuroendovascular therapy · 2026Review
- Overlapping Flow Diverter with Coiling for Fetal-type Posterior Communicating Artery Aneurysms with Triple Antithrombotic Therapy: A Case Series.NMC case report journal · 2026Article
- Adjunctive Coiling in Flow Diverter Treatment Does Not Prevent Delayed Rupture: A Nationwide Survey.Neurointervention · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe use of a Pipeline Embolization Device (PED) in combination with coils (PEDC) to treat intracranial aneurysms remains unclear as to whether it offers significant benefits for the patients because the results have varied. PURPOSE: This study aimed to investigate the clinical outcome of the PEDC compared with the PED in treating intracranial aneurysms. DATA SOURCES: We systematically searched the articles from PubMed, Web of Science, and the Cochrane Library databases published before January 25, 2024. STUDY SELECTION: We selected studies comparing the PEDC versus the PED to treat intracranial aneurysms. Patients treated with the PEDC but using dense coiling were excluded from the study. DATA ANALYSIS: The clinical outcomes observed in this meta-analysis were intraprocedural complications, postoperative complications (stenosis, stroke, hemorrhage, mortality), favorable outcome (mRS ≤2), complete occlusion rate, and retreatment rate. A forest plot was used to analyze pooled OR of clinical outcomes. DATA SYNTHESIS: A total of 3001 subjects from 9 observational studies were included. The PEDC was mainly used to treat larger aneurysms. The PEDC has a significantly higher complete occlusion rate at 6 months (OR = 2.66; 95% CI, 1.26-115.59; LIMITATIONS: No randomized controlled trials have been performed comparing the PEDC and PED. Considering that all the included studies were observational, the patients' baseline characteristics were not completely balanced.
conclusionsThis meta-analysis study showed that the PEDC in large intracranial aneurysms induces a faster complete occlusion rate at 6 months and a lower retreatment rate. However, it increases the risk of stroke-related postoperative complications, and the faster complete aneurysm occlusion rate found in this study did not correlate with a reduction in long-term aneurysm or distal artery ruptures. Thus, this study suggests the need to find a better strategy to improve long-term hemorrhage-related complications in large intracranial aneurysms.
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