ArticleAJNR. American journal of neuroradiology2025
Quantification of Collateral Supply with Local-AIF Dynamic Susceptibility Contrast MRI Predicts Infarct Growth.
Article in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Comparative evaluation of dynamic susceptibility contrast MRI techniques for brain imaging at 3T and 5T magnetic field strengths.Frontiers in human neuroscience · 2026Article
- Dynamic Impact of Leptomeningeal Collateral Status for Hemorrhagic Transformation in Patients with Acute Ischemic Stroke with Endovascular Treatment: A Prospective Study.Neurocritical care · 2025Article
- Estimation of multicomponent flow in the kidney with multi-b-value spectral diffusion.Magnetic resonance in medicine · 2025Article
- Assessment of Variability in Cerebral Blood Flow and Cerebral Blood Volume in Cerebral Arteries of Ischemic Stroke Patients Using Dynamic Contrast-Enhanced MRI.Tomography (Ann Arbor, Mich.) · 2025Article
- Article
- A Method for Imaging the Ischemic Penumbra with MRI Using Intravoxel Incoherent Motion.AJNR. American journal of neuroradiology · 2025Article
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Abstract
background and purposeIn ischemic stroke, leptomeningeal collaterals can provide delayed and dispersed compensatory blood flow to tissue-at-risk despite an occlusion and can impact treatment response and infarct growth. The purpose of this work is to test the hypothesis that the inclusion of this delayed and dispersed flow with an appropriately calculated local arterial input function (local-AIF) is needed to quantify the degree of collateral blood supply in tissue distal to an occlusion. MATERIALS AND
methodsSeven experiments were conducted in a preclinical middle cerebral artery occlusion model. Dynamic susceptibility contrast MRI was imaged and postprocessed to yield quantitative cerebral blood flow (qCBF) maps with both a traditionally chosen single arterial input function applied globally to the whole brain (ie, "global-AIF") and a delay and dispersion corrected AIF (ie, "local-AIF") that is sensitive to retrograde flow. Leptomeningeal collateral arterial recruitment was quantified with a pial collateral score from x-ray angiograms, and infarct growth was calculated from serially acquired diffusion-weighted MRI scans.
resultsThe degree of collateralization at x-ray correlated more strongly with local-AIF qCBF in the ischemic penumbra (R
conclusionsIn acute stroke, qCBF calculated with a local-AIF is more accurate for assessing tissue status and collateral supply than traditionally chosen global-AIFs. These findings support the use of a local-AIF that corrects for delayed and dispersed retrograde flow in determining quantitative tissue perfusion with collateral supply in occlusive disease.
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