Evidence map›Paper›PMID 39134207›Full record

ArticleBrain stimulation

Electrographic seizures during low-current thalamic deep brain stimulation in mice.

Francisco J Flores, Isabella Dalla Betta, John Tauber, David R Schreier, Emily P Stephen, Matthew A Wilson, Emery N Brown

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Francisco J FloresDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Boston, 02114, MA, USA; Center for Brains, Minds, and Machines, Massachusetts Institute of Technology, 43 Vassar St, Cambridge, 02139, MA, USA; Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 43 Vassar St, Cambridge, 02139, MA, USA. Electronic address: fflores@mgh.harvard.edu.
Isabella Dalla BettaDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Boston, 02114, MA, USA; Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 43 Vassar St, Cambridge, 02139, MA, USA. Electronic address: idallabe@mit.edu.
John TauberDepartment of Mathematics and Statistics, Boston University, 665 Commonwealth Ave, Boston, 02215, MA, USA. Electronic address: jtauber@bu.edu.
David R SchreierDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Boston, 02114, MA, USA; Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 43 Vassar St, Cambridge, 02139, MA, USA; Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 101 Merrimac St, Boston, 02114, MA, USA; Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Freiburgstrasse 16, Bern, 3010, Switzerland. Electronic address: dschreier@mgh.harvard.edu.
Emily P StephenDepartment of Mathematics and Statistics, Boston University, 665 Commonwealth Ave, Boston, 02215, MA, USA. Electronic address: estephen@bu.edu.
Matthew A WilsonCenter for Brains, Minds, and Machines, Massachusetts Institute of Technology, 43 Vassar St, Cambridge, 02139, MA, USA; Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 43 Vassar St, Cambridge, 02139, MA, USA. Electronic address: mwilson@mit.edu.
Emery N BrownDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Boston, 02114, MA, USA; Center for Brains, Minds, and Machines, Massachusetts Institute of Technology, 43 Vassar St, Cambridge, 02139, MA, USA; Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 43 Vassar St, Cambridge, 02139, MA, USA; Institute for Medical Engineering and Sciences, Massachusetts Institute of Technology, 45 Carleton St, Cambridge, 02142, MA, USA. Electronic address: enbrown@neurostat.mit.edu.

Funding

Project 4: Mathematical Modeling Studies of Anesthetic ActionP01GM118269 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, EMERY N · 2017 to 2021
$9.0M
Non-Human Primate Model for Developing Closed-Loop Anesthesia Delivery SystemsR01NS123120 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI EMERY N BROWN · 2022 to 2026
$2.0M
NIGMS NIH HHS P01 GM118269NINDS NIH HHS R01 NS123120
6 · The paper itself

Abstract

backgroundDeep brain stimulation of the central thalamus (CT-DBS) has potential for modulating states of consciousness, but it can also trigger electrographic seizures, including poly-spike-wave trains (PSWT).

objectivesTo report the probability of inducing PSWTs during CT-DBS in awake, freely-moving mice.

methodsMice were implanted with electrodes to deliver unilateral and bilateral CT-DBS at different frequencies while recording electroencephalogram (EEG). We titrated stimulation current by gradually increasing it at each frequency until a PSWT appeared. Subsequent stimulations to test arousal modulation were performed at the current one step below the current that caused a PSWT during titration.

resultsIn 2.21% of the test stimulations (10 out of 12 mice), CT-DBS caused PSWTs at currents lower than the titrated current, including currents as low as 20 μA.

conclusionOur study found a small but significant probability of inducing PSWTs even after titration and at relatively low currents. EEG should be closely monitored for electrographic seizures when performing CT-DBS in both research and clinical settings.

Indexed as

Deep Brain StimulationElectroencephalographySeizuresThalamusAnimalsMaleMiceMice, Inbred C57BLDeep-brain stimulationElectric stimulationElectroencephalographySeizureThalamus

Identifiers

PMID39134207
PMCPMC11575467

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.